ArticleProceedings of the National Academy of Sciences of the United States of America2012
Epistasis in tomato color mutations involves regulation of phytoene synthase 1 expression by cis-carotenoids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93 citing papers in PubMed, 204 citations in OpenAlex.
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- Decoding Isoprenoid Transcript-Metabolite Interactions in Carotenoid Tomato Fruit Mutants Uncovers Novel Metabolic Cross-Links.International journal of molecular sciences · 2026Article
- Research progress on the regulatory mechanisms of the PSY promoter.Transgenic research · 2026Review
- The carotenoids metabolism during tomato fruit ripening: insights into multi-level regulatory network.BMC plant biology · 2026Review
- Association mapping of tomato fruit quality for weight, firmness, brix, and color using GWAS.BMC plant biology · 2025Article
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- Carotenoids in Potato Tubers: A Bright Yellow Future Ahead.Plants (Basel, Switzerland) · 2025Review
- Exogenous MeJA modulates postharvest tomato aroma by suppressing JAs-ethylene signaling crosstalk.Frontiers in plant science · 2025Article
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- Integrated metabolome and transcriptome analysis provides clues to fruit color formation of yellow, orange, and red bell pepper.Scientific reports · 2024Article
- The Y locus encodes a REPRESSOR OF PHOTOSYNTHETIC GENES protein that represses carotenoid biosynthesis via interaction with APRR2 in carrot.The Plant cell · 2024Article
- Green ripe fruit in tomato: unraveling the genetic tapestry from cultivated to wild varieties.Journal of experimental botany · 2024Article
- Genetic mapping and molecular marker development for white flesh color in tomato.Frontiers in plant science · 2024Article
- Multiomics analysis provides new insights into the regulatory mechanism of carotenoid biosynthesis in yellow peach peel.Molecular horticulture · 2023Article
- Overlapping and specialized roles of tomato phytoene synthases in carotenoid and abscisic acid production.Plant physiology · 2023Article
- Marker assisted early generation identification of root knot disease resistant orange tomato segregants with multiple desirable alleles.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tomato (Solanum lycopersicum) fruit accumulate the red carotenoid pigment lycopene. The recessive mutation yellow-flesh (locus r) in tomato eliminates fruit carotenoids by disrupting the activity of the fruit-specific phytoene synthase (PSY1), the first committed step in the carotenoid biosynthesis pathway. Fruits of the recessive mutation tangerine (t) appear orange due to accumulation of 7,9,7',9'-tetra-cis-lycopene (prolycopene) as a result of a mutation in the carotenoid cis-trans isomerase. It was established 60 y ago that tangerine is epistatic to yellow-flesh. This uncharacteristic epistasis interaction defies a paradigm in biochemical genetics arguing that mutations that disrupt enzymes acting early in a biosynthetic pathway are epistatic to other mutations that block downstream steps in the same pathway. To explain this conundrum, we have investigated the interaction between tangerine and yellow-flesh at the molecular level. Results presented here indicate that allele r(2997) of yellow-flesh eliminates transcription of PSY1 in fruits. In a genetic background of tangerine, transcription of PSY1 is partially restored to a level sufficient for producing phytoene and downstream carotenoids. Our results revealed the molecular mechanism underlying the epistasis of t over r and suggest the involvement of cis-carotenoid metabolites in a feedback regulation of PSY1 gene expression.
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