ArticleProceedings of the National Academy of Sciences of the United States of America2012
Bottom-up construction of in vitro switchable memories.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
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- Multiplexed and high-bandwidth DNA computing circuits with superresolution DNA origami displays.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intelligent molecular logic computing toolkits: nucleic acid-based construction, functionality, and enhanced biosensing applications.Chemical science · 2025Review
- CRISPR/Cas12a DTR system: a topology-guided Cas12a assay for specific dual detection of RNA and DNA targets.Nucleic acids research · 2025Article
- Implementing complex nucleic acid circuits in living cells.Science advances · 2025Article
- Autonomous assembly and disassembly of gliding molecular robots regulated by a DNA-based molecular controller.Science advances · 2024Article
- DNA droplets for intelligent and dynamical artificial cells: from the viewpoint of computation and non-equilibrium systems.Interface focus · 2023Review
- Standardized excitable elements for scalable engineering of far-from-equilibrium chemical networks.Nature chemistry · 2022Article
- An Account of Models of Molecular Circuits for Associative Learning with Reinforcement Effect and Forced Dissociation.Sensors (Basel, Switzerland) · 2022Article
- Protocellular CRISPR/Cas-Based Diffusive Communication Using Transcriptional RNA Signaling.Angewandte Chemie (International ed. in English) · 2022Article
- Dissipative DNA nanotechnology.Nature chemistry · 2022Review
- Memory, switches, and an OR-port through bistability in chemically fueled crystals.Nature communications · 2022Article
- Controlling the Synchronization of Molecular Oscillators through Indirect Coupling.Micromachines · 2022Article
- Reversible and spatiotemporal control of colloidal structure formation.Nature communications · 2021Article
- DNAzyme- and light-induced dissipative and gated DNA networks.Chemical science · 2021Article
- A last-in first-out stack data structure implemented in DNA.Nature communications · 2021Article
- Signaling in Systems Chemistry: Programing Gold Nanoparticles Formation and Assembly Using a Dynamic Bistable Network.Angewandte Chemie (International ed. in English) · 2021Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reaction networks displaying bistability provide a chemical mechanism for long-term memory storage in cells, as exemplified by many epigenetic switches. These biological systems are not only bistable but switchable, in the sense that they can be flipped from one state to the other by application of specific molecular stimuli. We have reproduced such functions through the rational assembly of dynamic reaction networks based on basic DNA biochemistry. Rather than rewiring genetic systems as synthetic biology does in vivo, our strategy consists of building simplified dynamic analogs in vitro, in an artificial, well-controlled milieu. We report successively a bistable system, a two-input switchable memory element, and a single-input push-push memory circuit. These results suggest that it is possible to build complex time-responsive molecular circuits by following a modular approach to the design of dynamic in vitro behaviors. Our approach thus provides an unmatched opportunity to study topology/function relationships within dynamic reaction networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.