ArticleEuropean journal of immunology2013
Lymphotoxin α1β2 expression on B cells is required for follicular dendritic cell activation during the germinal center response.
Article in European journal of immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Defining the rules of engagement: B cells, antibodies and cancer control.Cellular & molecular immunology · 2026Review
- Lymphotoxin beta receptorInfection and immunity · 2025Article
- B cells are not drivers of stromal cell activation during acute CNS infection.Journal of neuroinflammation · 2025Article
- Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas.European journal of immunology · 2022Article
- Lymphoid stromal cells-more than just a highway to humoral immunity.Oxford open immunology · 2021Review
- Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB.Cell reports · 2019Article
- Autoreactive B cells in SLE, villains or innocent bystanders?Immunological reviews · 2019Review
- Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Reduced lymphotoxin-beta production by tumour cells is associated with loss of follicular dendritic cell phenotype and diffuse growth in follicular lymphoma.The journal of pathology. Clinical research · 2018Article
- Regulation of the Germinal Center Response.Frontiers in immunology · 2018Review
- Survival of motor neurone protein is required for normal postnatal development of the spleen.Journal of anatomy · 2017Article
- ICOS Co-Stimulation: Friend or Foe?Frontiers in immunology · 2016Review
- Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.The Journal of clinical investigation · 2015Article
- The many faces of type I interferon in systemic lupus erythematosus.The Journal of clinical investigation · 2015Article
- Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection.Virology · 2014Article
- Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues.Frontiers in immunology · 2014Review
- B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia.PloS one · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
CD19-deficient mice were used as a model to study follicular dendritic cell (FDC) activation because these mice have normal numbers of FDC-containing primary follicles, but lack the ability to activate FDCs or form GCs. It was hypothesized that CD19 expression is necessary for B-cell activation and upregulation of membrane lymphotoxin (mLT) expression, which promotes FDC activation. Using VCAM-1 and FcγRII/III as FDC activation markers, it was determined that the adoptive transfer of CD19(+) wild-type B cells into CD19-deficient hosts rescued GC formation and FDC activation, demonstrating that CD19 expression on B cells is required for FDC activation. In contrast, CD19(+) donor B cells lacking mLT were unable to induce VCAM-1 expression on FDCs, furthermore FcγRII/III upregulation was impaired in FDCs stimulated with mLT-deficient B cells. VCAM-1 expression on FDCs, but not FcγRII/III, was rescued when CD19-deficient B cells expressing transgenic mLT were cotransferred into recipient mice with CD19(+) , mLT-deficient B cells, suggesting that FDC activation requires the CD19-dependent upregulation of mLT on activated B cells. Collectively, these data demonstrate that activated B cells are responsible for the initiation of FDC activation resulting in a microenvironment supportive of GC development and maintenance.
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