ArticleJournal of radiation research2012
Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced hepatopathy.
Article in Journal of radiation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model.Journal of clinical biochemistry and nutrition · 2022Article
- Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy.Journal of clinical biochemistry and nutrition · 2022Article
- Evaluation of the redox state in mouse organs following radon inhalation.Journal of radiation research · 2021Article
- Radon Exposure-Therapeutic Effect and Cancer Risk.International journal of molecular sciences · 2020Review
- Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map.Journal of radiation research · 2017Article
- Parenteral nutrition-associated liver injury and increased GRP94 expression prevented by ω-3 fish oil-based lipid emulsion supplementation.Journal of pediatric gastroenterology and nutrition · 2014Article
- Radon inhalation protects against transient global cerebral ischemic injury in gerbils.Inflammation · 2014Article
- Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid.International journal of nanomedicine · 2014Article
- Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation.Journal of radiation research · 2013Review
- Inhibitory effects of pretreatment with radon on acute alcohol-induced hepatopathy in mice.Mediators of inflammation · 2012Article
- Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood.Dose-response : a publication of International Hormesis SocietyArticle
- Changes of 8-OHdG and TrxR in the Residents Who Bathe in Radon Hot Springs.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl(4))-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl(4)-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and α-tocopherol on CCl(4)-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl(4) after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or α-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl(4)-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or α-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl(4) alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl(4)-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or α-tocopherol due to the induction of anti-oxidative functions.
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