ArticleJournal of neurologic physical therapy : JNPT2012
Aerobic exercise in subacute stroke improves cardiovascular health and physical performance.
Article in Journal of neurologic physical therapy : JNPT, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05706168 (A Study to Investigate the Effects of Aerobic Exercise Training), which is not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study to Investigate the Effects of Aerobic Exercise Training (AET) on the Large Intracranial and Extracranial Cerebral Arteries and the Cognitive and Motor Functions in Post Stroke Patients.
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Peripheral vascular function in stroke: systematic review and meta-analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Pooled it
- Are Aerobic Programs Similar in Design to Cardiac Rehabilitation Beneficial for Survivors of Stroke? A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2019Pooled it
- Secondary prevention lifestyle interventions initiated within 90 days after TIA or 'minor' stroke: a systematic review and meta-analysis of rehabilitation programmes.The British journal of general practice : the journal of the Royal College of General Practitioners · 2017Pooled it
- High-intensity interval training with robot-assisted gait therapy vs. treadmill gait therapy in chronic stroke: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial.Scientific reports · 2022Trial
- Two weeks of remote ischemic conditioning improves brachial artery flow mediated dilation in chronic stroke survivors.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Efficacy of Feedback-Controlled Robotics-Assisted Treadmill Exercise to Improve Cardiovascular Fitness Early After Stroke: A Randomized Controlled Pilot Trial.Journal of neurologic physical therapy : JNPT · 2015Trial
- Safety of aerobic exercise in people with diabetic peripheral neuropathy: single-group clinical trial.Physical therapy · 2015Trial
- Integrated virtual reality and musical biofeedback for intensity-guided training on stationary cycling: A comparative feasibility study.PLOS digital health · 2026Article
- Submaximal Exercise Testing to Dose High-Intensity Interval Training After Stroke: The FAST Randomized Clinical Trial.medRxiv : the preprint server for health sciences · 2026Article
- Stroke Recovery Program Incorporating Moderate-Intensity Aerobic Exercise Provides Sustained Improvement of Function: A 1-Year Follow-Up Study.Archives of rehabilitation research and clinical translation · 2026Article
- Vascular Health and Cutaneous Sensation are Predictive of Upper Limb Bone Loss in People with Stroke: A 2-Year Longitudinal Study.Calcified tissue international · 2026Article
- Modifiable and Non-Modifiable Predictors of Exercise Capacity in Stroke Survivors: A Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Fitness After Stroke Trial (FAST): Protocol for a Preliminary Efficacy Study of Recumbent Stepper High-Intensity Interval Training.Artery research · 2026Article
- Fitness After Stroke Trial (FAST): Protocol for a Preliminary Efficacy Study of Recumbent Stepper High-Intensity Interval Training.Research square · 2025Article
- Efficacy of Physical Therapy Rehabilitation in the Cardiovascular Deconditioning of Post-Stroke Survivors: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Feasibility of a Recumbent Stepper for Short-Interval, Low-Volume High-Intensity Interval Exercise in Stroke.Journal of neurologic physical therapy : JNPT · 2025Article
- Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Mechanisms and benefits of cardiac rehabilitation in individuals with stroke: emerging role of its impact on improving cardiovascular and neurovascular health.Frontiers in cardiovascular medicine · 2024Review
- Financial analysis of a locomotor exercise trial for post-stroke recovery: insights from the HIT Stroke Trial.Frontiers in stroke · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeCardiovascular health is often impaired after stroke. Reduced exercise capacity ((Equation is included in full-text article.)VO(2peak)) and changes in the vascular system in the stroke-affected limb may impact performance of physical activities such as walking. There is little information regarding the role of prescribed moderate- to high-intensity exercise in subacute stroke. The purpose of this study was to examine whether an 8-week aerobic exercise intervention would improve cardiovascular health and physical performance in participants with subacute stroke.
methodsTen subjects were enrolled in the study and 9 of them completed the intervention. Participants were aged 61.2 ± 4.7 years old, were 66.7 ± 41.5 days poststroke, and had minor motor performance deficits (Fugl-Meyer score, 100.3 ± 29.3). Outcome measures were taken at baseline, postintervention, and at 1-month follow-up. Brachial artery vasomotor reactivity (flow-mediated dilation [FMD]) of both arms was used to assess vascular health, and a peak exercise test was used to assess exercise capacity. The 6-minute walk test (6MWT) was used to assess physical performance. Participants exercised on a recumbent stepper 3 times per week for 8 weeks at a prescribed heart rate intensity.
resultsAt baseline, we identified between-limb differences in brachial artery FMD and low (Equation is included in full-text article.)VO(2peak) values. After the intervention, significant improvements were observed in the FMD in both arms, resting systolic blood pressure, and the 6MWT. Although we also observed improvements in the resting diastolic blood pressure, heart rate, and (Equation is included in full-text article.)VO(2peak) values, these changes were not significantly different. DISCUSSION AND
conclusionAerobic exercise in participants with subacute stroke was beneficial for improving cardiovascular health, reducing cardiac risk, and improving physical performance (6MWT).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.