ReviewCurrent opinion in pediatrics2012
Normal neonatal microbiome variation in relation to environmental factors, infection and allergy.
Review in Current opinion in pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03239197 (An Exploratory Study to Evaluate the Transfer of the Maternal Microbial Consortia to Infants During and Following Birth), which is not on this map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Exploratory Study to Evaluate the Transfer of the Maternal Microbial Consortia to Infants During and Following Birth
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Impact of mode of birth and perinatal antibiotics on infant gut microbiota and health: a systematic review and meta-analysis.BMJ paediatrics open · 2026Pooled it
- Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial.The Journal of pediatrics · 2021Trial
- A Mixed-method Study on Dietary Diversity and Factors Associated With Nutritional Status of Children Under 5 Years of Age in a District of Central India.Annals of African medicine · 2026Article
- Combination of Tripterygium glycosides and Lactobacillus paracasei sensitises epithelial ovarian cancer to cisplatin via downregulating Keap1-Nrf2-GPX4 signalling pathway.Cellular & molecular biology letters · 2026Article
- Dietary Fatty Acids Modulate Gut Microbiota-Derived Trimethylamine-N-Oxide: Potential Mechanisms and Future Perspective.Nutrients · 2025Review
- Article
- Gram-Negative Colonization and Bacterial Translocation Drive Neonatal Sepsis in the Indian Setting.Journal of epidemiology and global health · 2024Article
- Environmental microbiome in the home and daycare settings during the COVID-19 pandemic, and potential risk of non-communicable disease in children.Environmental microbiology reports · 2024Article
- Early life acute infections and risk for cow's milk protein allergy or atopic dermatitis at 6 months of age in high risk for allergy infants.Frontiers in pediatrics · 2024Article
- Review
- Review
- Incidence Rate and Associated Factors of Early Onset Sepsis Among Neonate Born at ≥35 Weeks' Gestation in Thai Tertiary Hospital.Infection and drug resistance · 2023Article
- Role of gut-brain axis in neurodevelopmental impairment of necrotizing enterocolitis.Frontiers in neuroscience · 2023Review
- Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants.Exposure and health · 2022Article
- Allergic Inflammation: Effect of Propolis and Its Flavonoids.Molecules (Basel, Switzerland) · 2022Review
- Bacterial colonization and TH17 immunity are shaped by intestinal sialylation in neonatal mice.Glycobiology · 2022Article
- Current understanding of the human microbiome in glioma.Frontiers in oncology · 2022Review
- Longitudinal Multi-Omics Study of a Mother-Infant Dyad from Breastfeeding to Weaning: An Individualized Approach to Understand the Interactions Among Diet, Fecal Metabolome and Microbiota Composition.Frontiers in molecular biosciences · 2021Article
- Review
- Early Life Stress and the Development of the Infant Gut Microbiota: Implications for Mental Health and Neurocognitive Development.Current psychiatry reports · 2020Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
purpose of reviewBacterial colonization of the infant intestinal tract begins at birth. We are at the forefront of understanding complex relationships between bacteria and multiple parameters of health of the developing infant. Moreover, the establishment of the microbiome in the critical neonatal period is potentially foundational for lifelong health and disease susceptibility. Recent studies utilizing state-of-the-art culture-independent technologies have begun to increase our knowledge about the gut microbiome in infancy, the impact of multiple exposures, and its effects on immune response and clinical outcomes such as allergy and infection. RECENT
findingsPostnatal exposures play a central role in the complex interactions between the nearly blank canvas of the neonatal intestine, whereas genetic factors do not appear to be a major factor. Infant microbial colonization is affected by delivery mode, dietary exposures, antibiotic exposure, and environmental toxicants. Successive microbiome acquisition in infancy is likely a determinant of early immune programming, subsequent infection, and allergy risk. SUMMARY: The novel investigation of the neonatal microbiome is beginning to unearth substantial information, with a focus on immune programming that coevolves with the developing microbiome early in life. Several exposures common to neonatal and infant populations could exert pressure on the development of the microbiome and major diseases including allergy and infection in large populations.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.