Evidence map›Paper›PMID 23111104›Full record

ReviewCancer letters2013

Cancer genome sequencing: understanding malignancy as a disease of the genome, its conformation, and its evolution.

Lalit R Patel, Matti Nykter, Kexin Chen, Wei Zhang

Abstract readReview
In one paragraph

Review in Cancer letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. The Impact of Genetic Counseling Educational Tools on Patients' Knowledge of Molecular Testing Terminology.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020
    Article
  4. Article
  5. Challenges of deciphering gastric cancer heterogeneity.World journal of gastroenterology · 2015
    Review
  6. The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL).Clinical cancer research : an official journal of the American Association for Cancer Research · 2015
    Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lalit R PatelThe University of Texas Health Science Center, Houston, TX, USA; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Matti Nykter
Kexin Chen
Wei Zhang

Funding

Center for Systems Analysis of the Cancer RegulomeU24CA143835 · NCI · INSTITUTE FOR SYSTEMS BIOLOGY · PI SHMULEVICH, ILYA · 2009 to 2016
$10.6M
NCI NIH HHS U24 CA143835
6 · The paper itself

Abstract

Advances in cancer genomics have been propelled by the steady evolution of molecular profiling technologies. Over the past decade, high-throughput sequencing technologies have matured to the point necessary to support disease-specific shotgun sequencing. This has compelled whole-genome sequencing studies across a broad panel of malignancies. The emergence of high-throughput sequencing technologies has inspired new chemical and computational techniques enabling interrogation of cancer-specific genomic and transcriptomic variants, previously unannotated genes, and chromatin structure. Finally, recent progress in single-cell sequencing holds great promise for studies interrogating the consequences of tumor evolution in cancers presenting with genomic heterogeneity.

Indexed as

Evolution, MolecularGenome, HumanHigh-Throughput Nucleotide SequencingNucleic Acid ConformationSequence Analysis, DNAAnimalsBiomarkers, TumorComputational BiologyDNA Mutational AnalysisGene Expression ProfilingGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGenetic TestingGenomicsHumansNeoplasmsBiomarkers, TumorBioinformaticsCancer genomicsChromosomal conformation sequencingNext-generation sequencingTranscriptomicsTumor heterogeneity

Identifiers

PMID23111104
PMCPMC3632661

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.