ReviewThe Plant cell2012
Modeling regulatory networks to understand plant development: small is beautiful.
Review in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- A BRC1-modulated switch in auxin efflux accounts for the competition between Arabidopsis axillary buds.PLoS biology · 2025Article
- Design principles for synthetic control systems to engineer plants.Plant cell reports · 2023Review
- Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments.Scientific reports · 2022Article
- The Nucleolar Fibrillarin Protein Is Required for Helper Virus-Independent Long-Distance Trafficking of a Subviral Satellite RNA in Plants.The Plant cell · 2016Article
- FlexFlux: combining metabolic flux and regulatory network analyses.BMC systems biology · 2015Article
- Modelling hormonal response and development.Trends in plant science · 2014Review
- Plant and animal stem cells: similar yet different.Nature reviews. Molecular cell biology · 2014Review
- Light intensity modulates the regulatory network of the shade avoidance response in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Regulatory network features in Listeria monocytogenes-changing the way we talk.Frontiers in cellular and infection microbiology · 2014Review
- Root systems biology: integrative modeling across scales, from gene regulatory networks to the rhizosphere.Plant physiology · 2013Review
- Network component analysis provides quantitative insights on an Arabidopsis transcription factor-gene regulatory network.BMC systems biology · 2013Article
- Genome-scale cold stress response regulatory networks in ten Arabidopsis thaliana ecotypes.BMC genomics · 2013Article
- Gene regulatory networks in plants: learning causality from time and perturbation.Genome biology · 2013Article
- An interdisciplinary view on dynamic models for plant genetics and morphogenesis: scope, examples and emerging research avenues.Frontiers in plant science · 2013Article
- Vertex-element models for anisotropic growth of elongated plant organs.Frontiers in plant science · 2013Article
- In silico plant biology comes of age.The Plant cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We now have unprecedented capability to generate large data sets on the myriad genes and molecular players that regulate plant development. Networks of interactions between systems components can be derived from that data in various ways and can be used to develop mathematical models of various degrees of sophistication. Here, we discuss why, in many cases, it is productive to focus on small networks. We provide a brief and accessible introduction to relevant mathematical and computational approaches to model regulatory networks and discuss examples of small network models that have helped generate new insights into plant biology (where small is beautiful), such as in circadian rhythms, hormone signaling, and tissue patterning. We conclude by outlining some of the key technical and modeling challenges for the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.