Evidence map›Paper›PMID 23110433›Full record

ReviewJournal of the American Geriatrics Society2012

Gait and cognition: a complementary approach to understanding brain function and the risk of falling.

Manuel Montero-Odasso, Joe Verghese, Olivier Beauchet, Jeffrey M Hausdorff

5 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 477 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
477citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02740530 naterminatednot on this mapstarted 2016, after this paper: background citation

Improving Mobility and Cognition in Older Adults: Establishment of an Interdisciplinary Clinical Research Program Using Non-Invasive Brain Stimulation

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2023Enrolled25ConditionsExecutive Dysfunction, Gait Performance, Repetitive Transcranial Magnetic StimulationArmsMagstim® Rapid 2 machine
NCT02808676 naterminatednot on this mapstarted 2016, after this paper: background citation

SYNchronizing Exercises, Remedies in GaIt and Cognition (SYNERGIC): A Randomized Controlled Double Blind Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2020Enrolled175ConditionsMild Cognitive ImpairmentArmsVitamin D3, Exercises (E), Cognitive Training (CT), placebo D3, control cognitive training
NCT07547111 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of the Effectiveness of Dual-Task Training and Computer-Based Cognitive Rehabilitation in Older Adults With Mild Cognitive Impairment

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2026 to 2027Enrolled42ConditionsMild Cognitive Impairment (MCI)ArmsDual Task Training, The computer-assisted cognitive rehabilitation
NCT07586553 recruitingnot on this mapstarted 2026, after this paper: background citation

Validity and Reliability of the Figure-of-8 Walk Test (8FWT) in Individuals With Motoric Cognitive Risk Syndrome

TypeobservationalSponsorBalikesir UniversityRan2026 to 2026Enrolled52ConditionsMotoric Cognitive Risk Syndrome, Gait, BalanceArmsAssessment Protocol
NCT07753421 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

The Relationship Between Comorbidity Burden, Cognitive Function, Gait Speed, and Respiratory Muscle Strength in Community-Dwelling Older Adults: A Cross-Sectional Observational Study

TypeobservationalSponsorAcibadem UniversityRan2026 to 2027Enrolled66ConditionsGeriatrics, Older Adults (60 - 85 Years Old), Aging
3 · Its place in the literature

Who cites it

477 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Association of the Timed Up and Go Test With Alzheimer's Disease: Systematic Review and Meta-Analysis.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
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417 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Manuel Montero-OdassoDivision of Geriatric Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. mmontero@uwo.ca
Joe Verghese
Olivier Beauchet
Jeffrey M Hausdorff

Funding

Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI CAROL A. DERBY · 1985 to 2026
$73.9M
Latent Mobility Abnormalities And FrailtyR01AG025119 · NIA · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI VERGHESE, JOE · 2005 to 2009
$1.5M
Gait instability in the elderly with increased fall riskR01AG014100 · NIA · TEL-AVIV SOURASKY MEDICAL CENTER · PI HAUSDORFF, JEFFREY M · 2005 to 2008
$531k
Ambulatory Monitoring of Near Falls: A Novel Measure of Fall RiskR21AG034227 · NIA · TEL-AVIV SOURASKY MEDICAL CENTER · PI HAUSDORFF, JEFFREY M · 2010 to 2011
$287k
CIHRNIA NIH HHS P01 AG003949NIA NIH HHS R01 AG014100NIA NIH HHS R01 AG025119NIA NIH HHS R21 AG034227PHS HHS P0I AGO03949
6 · The paper itself

Abstract

Until recently, clinicians and researchers have performed gait assessments and cognitive assessments separately when evaluating older adults, but increasing evidence from clinical practice, epidemiological studies, and clinical trials shows that gait and cognition are interrelated in older adults. Quantifiable alterations in gait in older adults are associated with falls, dementia, and disability. At the same time, emerging evidence indicates that early disturbances in cognitive processes such as attention, executive function, and working memory are associated with slower gait and gait instability during single- and dual-task testing and that these cognitive disturbances assist in the prediction of future mobility loss, falls, and progression to dementia. This article reviews the importance of the interrelationship between gait and cognition in aging and presents evidence that gait assessments can provide a window into the understanding of cognitive function and dysfunction and fall risk in older people in clinical practice. To this end, the benefits of dual-task gait assessments (e.g., walking while performing an attention-demanding task) as a marker of fall risk are summarized. A potential complementary approach for reducing the risk of falls by improving certain aspects of cognition through nonpharmacological and pharmacological treatments is also presented. Untangling the relationship between early gait disturbances and early cognitive changes may be helpful in identifying older adults at risk of experiencing mobility decline, falls, and progression to dementia.

Indexed as

Accidental FallsCognitionGaitAgedAged, 80 and overBrainCognition DisordersHumansPostural BalanceRisk

Identifiers

PMID23110433
PMCPMC3498517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.