Trial reportPloS one2012
Influence of acute jugular vein compression on the cerebral blood flow velocity, pial artery pulsation and width of subarachnoid space in humans.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Influence of a neck compression collar on cerebrovascular and autonomic function in men and women.PloS one · 2019Trial
- Trial
- Anatomical Reasons for an Impaired Internal Jugular Flow.Medicina (Kaunas, Lithuania) · 2025Review
- Article
- Effects of intubation technique on intracranial pressure: a cadaveric study.Neurosurgical review · 2023Article
- Approach considerations for the management of strangulation in the emergency department.Journal of the American College of Emergency Physicians open · 2022Article
- Variations of human cerebral and ocular blood flow during exposure to multi-axial accelerations : A mathematical modeling study.Medical & biological engineering & computing · 2022Article
- Subarachnomegaly-venous congestion of infancy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- [Intraoperative vascular air embolism : Evidence for risks, diagnostics and treatment].Der Anaesthesist · 2021Review
- Sleep-Disordered Breathing and Idiopathic Normal-Pressure Hydrocephalus: Recent Pathophysiological Advances.Current neurology and neuroscience reports · 2019Review
- No Established Link between Repeated Transient Chokes and Chronic Traumatic Encephalopathy Related Effects. Comment on Lim, L.J.H. et al. Dangers of Mixed Martial Arts in the Development of Chronic Traumatic Encephalopathy.International journal of environmental research and public health · 2019Article
- Cerebro-venous hypertension: a frequent cause of so-called "external hydrocephalus" in infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Human subarachnoid space width oscillations in the resting state.Scientific reports · 2018Article
- Ultrasound diagnosis of transverse sinus hypoplasia using flow profiles of the internal jugular vein.PloS one · 2017Article
- Article
- Article
- Intrajugular balloon catheter reduces air embolism in vitro and in vivo.British journal of anaesthesia · 2015Article
- Article
- Effect of Maximal Apnoea Easy-Going and Struggle Phases on Subarachnoid Width and Pial Artery Pulsation in Elite Breath-Hold Divers.PloS one · 2015Article
- Internal jugular vein blood flow in multiple sclerosis patients and matched controls.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to assess the effect of acute bilateral jugular vein compression on: (1) pial artery pulsation (cc-TQ); (2) cerebral blood flow velocity (CBFV); (3) peripheral blood pressure; and (4) possible relations between mentioned parameters.
methodsExperiments were performed on a group of 32 healthy 19-30 years old male subjects. cc-TQ and the subarachnoid width (sas-TQ) were measured using near-infrared transillumination/backscattering sounding (NIR-T/BSS), CBFV in the left anterior cerebral artery using transcranial Doppler, blood pressure was measured using Finapres, while end-tidal CO(2) was measured using medical gas analyser. Bilateral jugular vein compression was achieved with the use of a sphygmomanometer held on the neck of the participant and pumped at the pressure of 40 mmHg, and was performed in the bend-over (BOPT) and swayed to the back (initial) position.
resultsIn the first group (n = 10) during BOPT, sas-TQ and pulse pressure (PP) decreased (-17.6% and -17.9%, respectively) and CBFV increased (+35.0%), while cc-TQ did not change (+1.91%). In the second group, in the initial position (n = 22) cc-TQ and CBFV increased (106.6% and 20.1%, respectively), while sas-TQ and PP decreases were not statistically significant (-15.5% and -9.0%, respectively). End-tidal CO(2) remained stable during BOPT and venous compression in both groups. Significant interdependence between changes in cc-TQ and PP after bilateral jugular vein compression in the initial position was found (r = -0.74).
conclusionsAcute bilateral jugular venous insufficiency leads to hyperkinetic cerebral circulation characterised by augmented pial artery pulsation and CBFV and direct transmission of PP into the brain microcirculation. The Windkessel effect with impaired jugular outflow and more likely increased intracranial pressure is described. This study clarifies the potential mechanism linking jugular outflow insufficiency with arterial small vessel cerebral disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.