ArticlePloS one2012
Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Identification of multiple public TCR repertoires in chronic beryllium disease.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Tracking of activated cTfh cells following sequential influenza vaccinations reveals transcriptional profile of clonotypes driving a vaccine-induced immune response.Frontiers in immunology · 2023Article
- Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes.Biomedicines · 2022Article
- SARS-CoV-2 vaccination diversifies the CD4+ spike-reactive T cell repertoire in patients with prior SARS-CoV-2 infection.EBioMedicine · 2022Article
- Perturbations in the T cell receptor β repertoire during malaria infection in children: A preliminary study.Frontiers in immunology · 2022Article
- Limited TCR repertoire andiScience · 2021Article
- Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals.Scientific reports · 2021Article
- In chronic infection, HIV gag-specific CD4+ T cell receptor diversity is higher than CD8+ T cell receptor diversity and is associated with less HIV quasispecies diversity.Journal of virology · 2021Article
- Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8Frontiers in immunology · 2021Article
- T cell receptor sequencing in autoimmunity.Journal of life sciences (Westlake Village, Calif.) · 2020Article
- MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors.BMC immunology · 2019Article
- Expanded TCRβ CDR3 clonotypes distinguish Crohn's disease and ulcerative colitis patients.Mucosal immunology · 2018Article
- Article
- CD154 Costimulation Shifts the Local T-Cell Receptor Repertoire Not Only During Thymic Selection but Also During Peripheral T-Dependent Humoral Immune Responses.Frontiers in immunology · 2018Article
- Shared αβ TCR Usage in Lungs of Sarcoidosis Patients with Löfgren's Syndrome.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Impaired T-cell differentiation in diabetic foot ulceration.Cellular & molecular immunology · 2017Article
- Autoimmunity and the microbiome: T-cell receptor mimicry of "self" and microbial antigens mediates self tolerance in holobionts: The concepts of "holoimmunity" (TcR-mediated tolerance for the holobiont) and "holoautoimmunity" (loss of tolerance for the holobiont) are introduced.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Article
- Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Paired TCRαβ analysis of virus-specific CD8(+) T cells exposes diversity in a previously defined 'narrow' repertoire.Immunology and cell biology · 2015Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe importance of CD4⁺ and CD8⁺ T cells in protection against tuberculosis (TB) is well known, however, the association between changes to the T cell repertoire and disease presentation has never been analyzed. Characterization of T-cells in TB patients in previous study only analyzed the TCR β chain and omitted analysis of the Vα family even though α chain also contribute to antigen recognition. Furthermore, limited information is available regarding the heterogeneity compartment and overall function of the T cells in TB patients as well as the common TCR structural features of Mtb antigen specific T cells among the vast numbers of TB patients. METHODOLOGY/PRINCIPAL
findingsCDR3 spectratypes of CD4⁺ and CD8⁺ T cells were analyzed from 86 patients with TB exhibiting differing degrees of disease severity, and CDR3 spectratype complexity scoring system was used to characterize TCR repertoire diversity. TB patients with history of other chronic disease and other bacterial or viral infections were excluded for the study to decrease the likely contribution of TCRs specific to non-TB antigens as far as possible. Each patient was age-matched with a healthy donor group to control for age variability. Results showed that healthy controls had a normally diversified TCR repertoire while TB patients represented with restricted TCR repertoire. Patients with mild disease had the highest diversity of TCR repertoire while severely infected patients had the lowest, which suggest TCR repertoire diversity inversely correlates with disease severity. In addition, TB patients showed preferred usage of certain TCR types and have a bias in the usage of variable (V) and joining (J) gene segments and N nucleotide insertions. CONCLUSIONS/SIGNIFICANCE: Results from this study promote a better knowledge about the public characteristics of T cells among TB patients and provides new insight into the TCR repertoire associated with clinic presentation in TB patients.
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