ArticlePloS one2012
Natural transmission of Plasmodium berghei exacerbates chronic tuberculosis in an experimental co-infection model.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Co-infection of tuberculosis and parasitic diseases in humans: a systematic review.Parasites & vectors · 2013Pooled it
- Impact of co-infection with Plasmodium berghei ANKA in Leishmania major-parasitized mice on immune modulation and cutaneous leishmaniasis.PLoS neglected tropical diseases · 2025Article
- Concomitant Splenic Tuberculosis and Epstein-Barr Virus-Related T-Cell Leukemia/Lymphoma in a 28-Year-Old Pregnant Woman in South Sudan.The American journal of tropical medicine and hygiene · 2025Article
- Malaria and tuberculosis co-infection-a review.Oxford open immunology · 2023Review
- Mouse Models forPathogens (Basel, Switzerland) · 2022Review
- Recent Advances in Host-Directed Therapies for Tuberculosis and Malaria.Frontiers in cellular and infection microbiology · 2022Review
- Sex differences in tuberculosis.Seminars in immunopathology · 2019Review
- Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda.Journal of tropical medicine · 2019Article
- Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?Frontiers in cellular and infection microbiology · 2018Review
- Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis.Mucosal immunology · 2017Article
- Tuberculosis arthritis of the sternoclavicular joint after uncomplicated falciparum malaria: a case report.Annals of clinical microbiology and antimicrobials · 2017Article
- Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection.Clinical and experimental immunology · 2017Article
- Mycobacterium tuberculosis Coinfection Has No Impact on Plasmodium berghei ANKA-Induced Experimental Cerebral Malaria in C57BL/6 Mice.Infection and immunity · 2016Article
- One Episode of Self-Resolving Plasmodium yoelii Infection Transiently Exacerbates Chronic Mycobacterium tuberculosis Infection.Frontiers in microbiology · 2016Article
- Tuberculosis Comorbidity with Communicable and Noncommunicable Diseases.Cold Spring Harbor perspectives in medicine · 2015Review
- An experimental model to study tuberculosis-malaria coinfection upon natural transmission of Mycobacterium tuberculosis and Plasmodium berghei.Journal of visualized experiments : JoVE · 2014Article
- Malarial pathocoenosis: beneficial and deleterious interactions between malaria and other human diseases.Frontiers in physiology · 2014Review
- The granuloma in tuberculosis: dynamics of a host-pathogen collusion.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Human populations are rarely exposed to one pathogen alone. Particularly in high incidence regions such as sub-Saharan Africa, concurrent infections with more than one pathogen represent a widely underappreciated public health problem. Two of the world's most notorious killers, malaria and tuberculosis, are co-endemic in impoverished populations in the tropics. However, interactions between both infections in a co-infected individual have not been studied in detail. Both pathogens have a major impact on the lung as the prime target organ for aerogenic Mycobacterium tuberculosis and the site for one of the main complications in severe malaria, malaria-associated acute respiratory distress syndrome (MA-ARDS). In order to study the ramifications caused by both infections within the same host we established an experimental mouse model of co-infection between Mycobacterium tuberculosis and Plasmodium berghei NK65, a recently described model for MA-ARDS. Our study provides evidence that malaria-induced immune responses impair host resistance to Mycobacterium tuberculosis. Using the natural routes of infection, we observed that co-infection exacerbated chronic tuberculosis while rendering mice less refractory to Plasmodium. Co-infected animals presented with enhanced inflammatory immune responses as reflected by exacerbated leukocyte infiltrates, tissue pathology and hypercytokinemia accompanied by altered T-cell responses. Our results--demonstrating striking changes in the immune regulation by co-infection with Plasmodium and Mycobacterium--are highly relevant for the medical management of both infections in humans.
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Registered trials
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