ArticleKorean journal of pathology2012
Expression of human papillomavirus-related proteins and its clinical implication in tonsillar squamous cell carcinoma.
Article in Korean journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Negative Prognostic Implication ofIndian journal of surgical oncology · 2021Article
- Positive Rate of Human Papillomavirus and Its Trend in Head and Neck Cancer in South Korea.Frontiers in surgery · 2021Article
- Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas.Journal of pathology and translational medicine · 2020Article
- Detection of HPV infection in head and neck cancers: Promise and pitfalls in the last ten years: A meta-analysis.Molecular and clinical oncology · 2019Article
- Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Human papillomavirus prevalence and cell cycle related protein expression in tonsillar squamous cell carcinomas of korean patients with clinicopathologic analysis.Korean journal of pathology · 2013Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundHuman papillomavirus (HPV) is known to cause of oropharyngeal squamous cell carcinoma (SqCC). HPV positive SqCCs overexpress p16 and are associated with better survival. Several markers of cell cycles and apoptosis have been reported as a prognostic value. We examined the prognostic value of HPV status, p16, cyclin D1, and Bcl-2 in patients with tonsillar SqCC.
methodsTissue microarrays were constructed in 56 cases of tonsillar SqCC for which we performed an immunohistochemistry and an in situ hybridization (ISH) of the HPV.
resultsOf the 56 cases, 31 (55.3%) were positive for p16 and 20 (35.7%) were positive for HPV ISH. The expressions of p16, cyclin D1, and Bcl-2 were not correlated with the clinicopathologic variables including smoking status, differentiation and pT- and pN-stages. The HPV ISH positive group showed a better overall survival than the HPV negative group (p=0.04), and the p16 positive group showed a better disease free survival (DFS) than the negative group (p=0.016). Cox regression analysis showed that only p16 positivity was an independent prognostic factor for DFS (p=0.03; hazard ratio, 10.1).
conclusionsOur results indicate that both p16 expression and HPV status are useful indicators for risk stratification in patients with tonsillar SqCC.
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