ArticleKorean journal of pathology2012
TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthritis in a Korean Population.
Article in Korean journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk.BMC musculoskeletal disorders · 2014Pooled it
- Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis.BMC musculoskeletal disorders · 2014Trial
- Osteoarthritis and analgesic consumption in haemochromatosis HFE C282Y homozygotes with normal or low iron parameters.Nature communications · 2026Article
- Causal effects of circulating inflammatory proteins on knee and hip osteoarthritis: A two sample Mendelian randomization study.Clinical rheumatology · 2025Article
- Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis.World journal of orthopedics · 2024Article
- The Exosomes of Stem Cells from Human Exfoliated Deciduous Teeth Suppress Inflammation in Osteoarthritis.International journal of molecular sciences · 2024Article
- Complement System Inhibition Modulates the Inflammation Induced by the Venom ofInternational journal of molecular sciences · 2022Article
- Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status.Biochemical genetics · 2022Article
- Complete sequence and comparative analysis of the mitochondrial genome of the rare and endangeredFrontiers in genetics · 2022Article
- Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.PloS one · 2021Article
- TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression.Frontiers in immunology · 2021Article
- Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults.Diabetes & metabolism journal · 2020Article
- Role of resistin genetic variations in knee osteoarthritis pathogenesis, a cross sectional study.Molecular biology reports · 2019Article
- Effect of a functional variant of tumor necrosis factor-β gene in temporomandibular disorders: A pilot study.Journal of clinical laboratory analysis · 2019Article
- TNF-α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis.Experimental and therapeutic medicine · 2018Article
- Association of cytokine gene polymorphisms with osteoarthritis susceptibility.Experimental and therapeutic medicine · 2018Article
- Association of TNF-α-308 G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis.Journal of orthopaedics · 2018Article
- Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- The single-nucleotide polymorphism (SNP) of tumor necrosis factor α -308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population.Clinical rheumatology · 2017Article
- The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis.Mediators of inflammation · 2014Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe tumor necrosis factor (TNF) is believed to play an important role in the pathophysiology of osteoarthritis (OA). Evidence shows that genetic polymorphisms make substantial contributions to the etiology of OA.
methodsWe investigated the genotypes TNF-α and TNF-β in 301 OA patients and 291 healthy subjects as controls. We employed a polymerase chain reaction-restriction fragment length polymorphism and a polymerase chain reaction-single strand conformation polymorphism assay to identify the genotypes TNFA -G308A and TNFB +G252A, respectively.
resultsFor TNFA -G308A, the percentages of genotypes GG, AG, and AA were 26.3% (79/301), 62.5% (188/301), and 11.3% (34/301) in OA patients and 88.7% (258/291), 11.3% (33/291), and 0% (0/291) in controls. For TNFB +G252A, the percentages of genotypes GG, AG, and AA were 15.3% (46/301), 41.9% (126/301), and 42.9% (129/301) in OA patients and 12% (35/291), 52.6% (153/291), and 35.4% (103/291) in controls. There were significant differences in genotypes and alleles of TNFA -308 between OA patients and controls (p<0.0001) and in alleles of TNFB +252 (p=0.0325). The risk of OA was significantly higher for carriers of the TNFA -308A allele and the TNFB +252 AA homozygote (p=0.0224).
conclusionsThe results suggest close relationships between TNFA -G308A and TNFB +G252A polymorphisms and individual susceptibility to OA in the Korean population.
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