ArticleInternational journal of molecular sciences2012
Prenatal vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Prenatal vitamin D deficiency exposure leads to long-term changes in immune cell proportions.Scientific reports · 2024Article
- Prenatal vitamin D supplementation mitigates inflammation-related alveolar remodeling in neonatal mice.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Autoimmune disease and interconnections with vitamin D.Endocrine connections · 2022Review
- Article
- Why monkeys do not get multiple sclerosis (spontaneously): An evolutionary approach.Evolution, medicine, and public health · 2018Review
- Maternal methyl donors supplementation during lactation prevents the hyperhomocysteinemia induced by a high-fat-sucrose intake by dams.International journal of molecular sciences · 2013Article
- Environmental factors acting during development to influence MS risk: insights from animal studies.Multiple sclerosis (Houndmills, Basingstoke, England) · 2013Review
- Serum levels of 25-hydroxy vitamin D in normal Biozzi and C57BL/6 mice and during the course of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE).Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous study, we demonstrated that mouse adult F(1) offspring, exposed to a vitamin D deficiency during pregnancy, developed a less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE), when compared with control offspring. We then wondered whether a similar response was observed in the subsequent generation. To answer this question, we assessed F(2) females whose F(1) parents (males or females) were vitamin D-deprived when developing in the uterus of F(0) females. Unexpectedly, we observed that the vitamin D deficiency affecting the F(0) pregnant mice induced a precocious and more severe EAE in the F(2) generation. This paradoxical finding led us to assess its implications for the epidemiology of Multiple Sclerosis (MS) in humans. Using the REFGENSEP database for MS trios (the patient and his/her parents), we collected the parents' dates of birth and assessed a potential season of birth effect that could potentially be indicative of the vitamin D status of the pregnant grandmothers. A trend for a reduced number of births in the Fall for the parents of MS patients was observed but statistical significance was not reached. Further well powered studies are warranted to validate the latter finding.
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Registered trials
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