Evidence map›Paper›PMID 23109779›Full record

ArticleTexas Heart Institute journal2012

Conivaptan therapy in an infant with severe hyponatremia and congestive heart failure.

Raj Sahu, Duraisamy Balaguru, Vandana Thapar, Ikram Haque, Chi Pham-Peyton, J Timothy Bricker

Open access · greenAbstract readCase Reports
In one paragraph

Article in Texas Heart Institute journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Raj SahuDivision of Pediatric Cardiology, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. SahuR@email.chop.edu
Duraisamy Balaguru
Vandana Thapar
Ikram Haque
Chi Pham-Peyton
J Timothy Bricker
The University of Texas Health Science Center at Houston · USMemorial Hermann · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conivaptan is a nonspecific arginine vasopressin receptor antagonist that has been used as therapy in adults who have hypervolemic hyponatremia due to congestive heart failure. Its use in children with congestive heart failure has not been reported. We describe the use of conivaptan in a 4-month-old infant girl with severe hypervolemic hyponatremia and heart failure. A therapeutic weight-based dose was extrapolated from the adult dose. Conivaptan therapy was administered for 48 hours, after which the patient recovered from her hyponatremia without untoward effects. Arginine vasopressin receptor antagonists such as conivaptan may be useful as therapy for hyponatremia associated with heart failure. Further studies are required before conivaptan can be recommended for routine use in children.

Indexed as

BenzazepinesFemaleHeart FailureHormone AntagonistsHumansHyponatremiaInfantNeurophysinsProtein PrecursorsSeverity of Illness IndexTreatment OutcomeVasopressinsAVP protein, humanBenzazepinesconivaptanHormone AntagonistsNeurophysinsProtein PrecursorsVasopressinsAntidiuretic agents/therapeutic useconivaptanheart failure/complicationshyponatremia/drug therapyreceptors, vasopressin/antagonists & inhibitorsrisk factorssodium/bloodtreatment outcome

Identifiers

PMID23109779
PMCPMC3461679
OpenAlexW1580241415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.