ArticleBulletin of the World Health Organization2012
Rotavirus mortality in India: estimates based on a nationally representative survey of diarrhoeal deaths.
Article in Bulletin of the World Health Organization, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 65 citations in OpenAlex.
- Trial
- Performance criteria for verbal autopsy-based systems to estimate national causes of death: development and application to the Indian Million Death Study.BMC medicine · 2014Trial
- Article
- Surveillance of Food and Waterborne Pathogens in North-East India: Protocol for a Laboratory-Based Sentinel Surveillance Study.JMIR research protocols · 2024Article
- Comparative Analysis of Enzyme-Linked Immunosorbent Assay and Immunochromatography for Rotavirus and Adenovirus Detection in Children below Five Years with Acute Gastroenteritis.Journal of laboratory physicians · 2023Article
- Article
- Gastroenteritis in Haryana, India Post Introduction of Rotavirus Vaccine.Indian journal of pediatrics · 2021Article
- Epidemiology and Genotype Distribution of Rotavirus Gastroenteritis in Under-Five Children of South Rajasthan, India.Indian journal of pediatrics · 2021Article
- Rotavirus Gastroenteritis Hospitalizations Among Under-Five Children in Bhubaneswar, Odisha, India.Indian journal of pediatrics · 2021Article
- Rotavirus Gastroenteritis in Eastern Uttar Pradesh, India.Indian journal of pediatrics · 2021Article
- Seasonal variation and etiologic inferences of childhood pneumonia and diarrhea mortality in India.eLife · 2019Article
- Cost-effectiveness analysis of introducing universal childhood rotavirus vaccination in Bangladesh.Human vaccines & immunotherapeutics · 2018Article
- Evaluation of data sources and approaches for estimation of influenza-associated mortality in India.Influenza and other respiratory viruses · 2018Article
- Facilitators and barriers for use of rotavirus vaccine amongst various stakeholders and its implications for Indian context - A systematic review.Human vaccines & immunotherapeutics · 2018Article
- Changes in cause-specific neonatal and 1-59-month child mortality in India from 2000 to 2015: a nationally representative survey.Lancet (London, England) · 2017Article
- An ensemble approach to predicting the impact of vaccination on rotavirus disease in Niger.Vaccine · 2017Article
- Observational
- Health impact and cost-effectiveness of a domestically-produced rotavirus vaccine in India: A model based analysis.PloS one · 2017Article
- Unusual rotavirus genotypes in humans and animals with acute diarrhoea in Northeast India.Epidemiology and infection · 2016Article
- Health utilization for childhood gastroenteritis in southern India.Indian journal of pediatrics · 2014Article
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11 authors at 9 institutions in 3 countries.
Funding
Abstract
objectiveTo estimate the number of rotavirus-associated deaths among Indian children younger than five years.
methodsWe surveyed more than 23 000 child deaths from a nationally representative survey of 1.1 million Indian households during 2001-2003. Diarrhoeal deaths were characterized by region, age and sex and were combined with the proportion of deaths attributable to rotavirus, as determined by hospital microbiologic data collected by the Indian Rotavirus Strain Surveillance Network from December 2005 to November 2007. Rotavirus vaccine efficacy data from clinical trials in developing countries were used to estimate the number of deaths preventable by a national vaccination programme. Data were analysed using Stata SE version 10.
findingsRotavirus caused an estimated 113 000 deaths (99% confidence interval, CI: 86 000-155 000); 50% (54 700) and 75% (85 400) occurred before one and two years of age, respectively. One child in 242 died from rotavirus infection before five years of age. Rotavirus-associated mortality rates overall, among girls and among boys were 4.14 (99% CI: 3.14-5.68), 4.89 (99% CI: 3.75-6.79) and 3.45 (99% CI: 2.58-4.66) deaths per 1000 live births, respectively. Rates were highest in Bihar, Uttar Pradesh and Madhya Pradesh, which together accounted for > 50% of deaths (64 400) nationally. Rotavirus vaccine could prevent 41 000-48 000 deaths among children aged 3-59 months.
conclusionThe burden of rotavirus-associated mortality is high among Indian children, highlighting the potential benefits of rotavirus vaccination.
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