Evidence map›Paper›PMID 23109488›Full record

ReviewPediatric blood & cancer2013

Positioning new treatments in the management of immune thrombocytopenia.

Donald M Arnold

Open access · greenAbstract readReview
In one paragraph

Review in Pediatric blood & cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Donald M ArnoldDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada. arnold@mcmaster.ca
Canadian Blood Services · CA

Funding

CIHR 102446-1
6 · The paper itself

Abstract

Immune thrombocytopenia (ITP) is a syndrome characterized by low platelet counts and an increased risk of bleeding. For most children, ITP is a self-limiting disease; however, for some children and most adults, thrombocytopenia can become chronic. Newer therapies for ITP include rituximab and thrombopoietin (TPO) receptor agonists. Rituximab is a useful second-line therapy and may be splenectomy-sparing. Thrombopoeitin receptor agonists have demonstrated large treatment effects with respect to increasing platelet levels; however, they require maintenance dosing. This review summarizes how these new agents might be positioned in the management of patients with chronic ITP.

Indexed as

Platelet CountAdultAntibodies, Monoclonal, Murine-DerivedBenzoatesBlood PlateletsChildHemorrhageHumansHydrazinesPurpura, Thrombocytopenic, IdiopathicPyrazolesReceptors, FcReceptors, ThrombopoietinRecombinant Fusion ProteinsRituximabThrombopoiesisAntibodies, Monoclonal, Murine-DerivedBenzoateseltrombopagHydrazinesMPL protein, humanPyrazolesReceptors, FcReceptors, ThrombopoietinRecombinant Fusion ProteinsRituximabromiplostimThrombopoietin

Identifiers

PMID23109488
PMCPMC4854632
OpenAlexW2127149281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.