ArticleContrast media & molecular imaging
In vivo real-time lymphatic draining using quantum-dot optical imaging in mice.
Article in Contrast media & molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multispectral Fluorescence Imaging as a Tool to Distinguish Pelvic Lymphatic Drainage Patterns During Robot-assisted Lymph Node Dissection in Prostate Cancer.Annals of surgical oncology · 2025Observational
- The stealth effect from a medicinal chemist perspective: definition and updates.Frontiers in drug delivery · 2025Article
- Fluorescent Tracers forFrontiers in pharmacology · 2022Review
- Designing inorganic nanomaterials for vaccines and immunotherapies.Nano today · 2019Article
- In vivo biodistribution and behavior of CdTe/ZnS quantum dots.International journal of nanomedicine · 2017Article
- Visualization of fluid drainage pathways in lymphatic vessels and lymph nodes using a mouse model to test a lymphatic drug delivery system.Biomedical optics express · 2015Article
- Nanoparticles: take only pictures, leave only footprints.Science translational medicine · 2014Article
- Emerging lymphatic imaging technologies for mouse and man.The Journal of clinical investigation · 2014Review
- Imaging aspects of the tumor stroma with therapeutic implications.Pharmacology & therapeutics · 2014Review
- Immunomodulation of nanoparticles in nanomedicine applications.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The lymphatic system is essential for fluid regulation and for the maintenance of host immunity. However, in vivo lymph flow is difficult to track in real time, because of the lack of an appropriate imaging method. In this study, we combined macro-zoom fluorescence microscopy with quantum-dot (Qdot) optical lymphatic imaging to develop an in vivo real-time optical lymphatic imaging method that allows the tracking of lymph through lymphatic channels and into lymph nodes. After interstitial injection of Qdots in a mouse, rapid visualization of the cervical lymphatics and cervical lymph nodes was achieved. Real-time monitoring of the injected Qdots revealed that the cortex of the node enhanced first followed by a net-like pattern in the central portion of the node. Histology revealed that the rim and net-like enhancing regions corresponded to the subcapsular sinuses and medullary sinuses respectively. Additionally, multiplexed two-color real-time lymphatic tracking was performed with two different Qdots. With this real-time imaging system, we successfully tracked microscopic lymphatic flow in vivo. This method could have a potential impact for lymphatic research in visualizing normal or abnormal functional lymphatic flows.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.