GuidelinePediatric blood & cancer2013
Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years.
Guideline in Pediatric blood & cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 261 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determination of Molecular Status, as Well as the Efficacy and Safety of Fluorodeoxyglucose (18F-FDG) in PET-CT Imaging in Juvenile Patients With Histiocytosis
A Multi-center, Open-label, Single-arm Study of Luvometinib Monotherapy in Pediatric Langerhans Cell Histiocytosis With Single-system Special-site Single and Multifocal Bone Involvement
Who cites it
261 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of oral lesions in Langerhans cell histiocytosis: a systematic review and meta-analysis.Oral and maxillofacial surgery · 2026Pooled it
- Eosinophilic granuloma of the calvarium: is conservative management a valid option? Illustrative case and systematic review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Pooled it
- Unisystem Langerhans cell histiocytosis in maxillofacial region in pediatrics: comprehensive and systematic review.Oral and maxillofacial surgery · 2021Pooled it
- Oral manifestation and gingival biopsy contributing to the early diagnosis of Langerhans cell histiocytosis in a paediatric patient.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics.Cancer metastasis reviews · 2026Review
- Histiocytosis development and clinical variation through the lens of genomics.The Journal of pathology · 2026Review
- Watchful waiting in children with unifocal osseous Langerhans cell histiocytosis.The oncologist · 2026Article
- Cytarabine-based induction and oral maintenance therapy for a single system with single-site Langerhans cell histiocytosis.International journal of hematology · 2026Article
- Cutaneous manifestations of pediatric Langerhans cell histiocytosis: A single-center case series from 2019 to 2024.JAAD case reports · 2026Article
- An Unusual Presentation of Multisystem Langerhans Cell Histiocytosis in a Child: A Case Report.Cureus · 2026Article
- Hearing loss in Langerhans cell histiocytosis: close association with central nervous system consequences.International journal of hematology · 2026Article
- Long-term MAPK inhibition of childhood refractory-Langerhans cell histiocytosis: an observational study of 288 patients.Blood advances · 2026Observational
- Solitary Diaphyseal Langerhans Cell Histiocytosis of Femur in an Infant - A Case Report.Journal of orthopaedic case reports · 2026Article
- Perianal Crohn-like disease in infancy revealing multisystem Langerhans cell histiocytosis.BMC pediatrics · 2026Article
- Dabrafenib or trametinib in pediatric Langerhans cell histiocytosis with bone lesions: a retrospective efficacy and safety study.BMC cancer · 2026Article
- Targeted therapy for Langerhans cell histiocytosis with maxillofacial involvement in 20 children.Orphanet journal of rare diseases · 2026Article
- What to do to beat Langerhans cell histiocytosis of bone? A narrative review and case series of radiofrequency ablation.EFORT open reviews · 2026Review
- Survival outcomes and adverse prognostic factors of Langerhans cell histiocytosis: a 40-year experience from a single tertiary center in Thailand.Annals of hematology · 2026Article
- Intravascular papillary endothelial hyperplasia presenting as a lytic frontal bone lesion in a pediatric male.Surgical neurology international · 2026Article
- Structural and functional hepatic factors as prognostic indicators in children with Langerhans cell histiocytosis.Frontiers in oncology · 2026Article
201 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work-up, and treatment and long-term follow-up of LCH patients are presented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.