ArticleJournal of inherited metabolic disease2013
Expression of the Nrf2-system at the blood-CSF barrier is modulated by neonatal inflammation and hypoxia-ischemia.
Article in Journal of inherited metabolic disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses.Neural plasticity · 2019Review
- The myth of the immature barrier systems in the developing brain: role in perinatal brain injury.The Journal of physiology · 2018Review
- The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury.Fluids and barriers of the CNS · 2017Review
- CSF Nrf2 and HSPA8 in Parkinson's disease patients with and without LRRK2 gene mutations.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- New means to assess neonatal inflammatory brain injury.Journal of neuroinflammation · 2015Review
- Expression of tight junction proteins and transporters for xenobiotic metabolism at the blood-CSF barrier during development in the nonhuman primate (P. hamadryas).Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Efflux transporters in blood-brain interfaces of the developing brain.Frontiers in neuroscience · 2015Review
- Conditioned media of choroid plexus epithelial cells induces Nrf2-activated phase II antioxidant response proteins and suppresses oxidative stress-induced apoptosis in PC12 cells.Journal of molecular neuroscience : MN · 2014Article
- NRF2-regulation in brain health and disease: implication of cerebral inflammation.Neuropharmacology · 2014Review
- Regulation of Toll-like receptors in the choroid plexus in the immature brain after systemic inflammatory stimuli.Translational stroke research · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transcription factor NF-E2-related factor-2 (Nrf2) is a key regulator of endogenous anti-oxidant systems shown to play a neuroprotective role in the adult by preserving blood-brain barrier function. The choroid plexus, site for the blood-CSF barrier, has been suggested to be particularly important in maintaining brain barrier function in development. We investigated the expression of Nrf2- and detoxification-system genes in choroid plexus following systemic LPS injections, unilateral cerebral hypoxia-ischemia (HI) as well as the combination of LPS and HI (LPS/HI). Plexuses were collected at different time points after LPS, HI and LPS/HI in 9-day old mice. mRNA levels of Nrf2 and many of its target genes were analyzed by quantitative PCR. Cell death was analyzed by caspase-3 immunostaining and TUNEL. LPS caused down-regulation of the Nrf2-system genes while HI increased expression at earlier time points. LPS exposure prior to HI prevented many of the HI-induced gene increases. None of the insults resulted in any apparent cell death to choroidal epithelium. These data imply that the function of the inducible anti-oxidant system in the choroid plexus is down-regulated by inflammation, even if choroid cells are not structurally damaged. Further, LPS prevented the endogenous antioxidant response following HI, suggesting the possibility that the choroid plexus may be at risk if LPS is united with an insult that increases oxidative stress such as hypoxia-ischemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.