ArticleJAMA neurology2013
Acute silent cerebral ischemic events in children with sickle cell anemia.
Article in JAMA neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00072761 (Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.BMC medicine · 2020Pooled it
- Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.Proteomics. Clinical applications · 2014Pooled it
- Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.The New England journal of medicine · 2014Trial
- Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment.Haematologica · 2024Article
- Neurocognitive outcome in children with sickle cell disease after myeloimmunoablative conditioning and haploidentical hematopoietic stem cell transplantation: a non-randomized clinical trial.Frontiers in neurology · 2024Article
- Hospitalizations among children with sickle cell disease enrolled in the Kumasi Sickle Cell Pan African Consortium (SPARCo) database: A cross sectional study.Health science reports · 2023Article
- Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia.Blood advances · 2023Article
- Quantitative susceptibility mapping (QSM) and R2Frontiers in neurology · 2022Article
- Individual Watershed Areas in Sickle Cell Anemia: An Arterial Spin Labeling Study.Frontiers in physiology · 2022Article
- Low Stroke Risk in Children With Sickle Cell Disease in French Guiana: A Retrospective Cohort Study.Frontiers in medicine · 2022Article
- Choroid plexus perfusion in sickle cell disease and moyamoya vasculopathy: Implications for glymphatic flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- MRI detection of brain abnormality in sickle cell disease.Expert review of hematology · 2021Article
- Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease.Radiology research and practice · 2021Article
- Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study.BMC pediatrics · 2019Article
- Vascular Instability and Neurological Morbidity in Sickle Cell Disease: An Integrative Framework.Frontiers in neurology · 2019Article
- Cerebral hemodynamic assessment and neuroimaging across the lifespan in sickle cell disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Stroke Prevalence in Children With Sickle Cell Disease in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.Global pediatric health · 2018Article
- Acute Chest Syndrome in Children with Sickle Cell Disease.Pediatric allergy, immunology, and pulmonology · 2017Review
- Enhanced Long-Term Brain Magnetic Resonance Imaging Evaluation of Children with Sickle Cell Disease after Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017Article
- Brain morphometric analysis predicts decline of intelligence quotient in children with sickle cell disease: A preliminary study.Advances in medical sciences · 2017Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundIrregular, sporadic episodes of ischemic brain injury are known to occur in sickle cell anemia (SCA), resulting in overt stroke and silent cerebral infarction. Ongoing ischemia in other organs is common in SCA but has never been documented in the brain.
objectiveTo test the hypothesis that acute silent cerebral ischemic events (ASCIEs) are frequent and potentially transient.
designCross-sectional and cohort study of children with SCA screened by magnetic resonance imaging (MRI) of the brain for a randomized clinical trial.
settingClinical trial setting in tertiary care centers. PATIENTS: Asymptomatic children with SCA without known stroke, neurologic injury, or epilepsy not receiving treatment with transfusions or hydroxyurea.
main outcome measureIncidence of ASCIEs calculated using single diffusion-weighted MRI scans (acute ischemic events that occurred within 10 days of the MRI).
resultsAcute silent cerebral ischemic events were detected on 1.3% of MRIs (10 of 771) in 652 children (mean age, 10.0 years), with an incidence of 47.3 events per 100 patient-years (95% CI, 22.7-87.2). Two of 10 children with ASCIEs had follow-up MRIs of the brain; only 1 had silent cerebral infarction in the same location as the previously detected ASCIE.
conclusionsChildren with SCA experience ongoing (chronic, intermittent) cerebral ischemia, sometimes reversible, far more frequently than previously recognized. The brain in SCA is at constant threat of ischemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.