ArticleInternational urogynecology journal2013
The polymorphisms of the MMP-1 and the MMP-3 genes and the risk of pelvic organ prolapse.
Article in International urogynecology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse.International urogynecology journal · 2022Pooled it
- Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women.American journal of obstetrics and gynecology · 2015Pooled it
- Genetic epidemiology of pelvic organ prolapse: a systematic review.American journal of obstetrics and gynecology · 2014Pooled it
- Verification of the Chromosome Region 9q21 Association with Pelvic Organ Prolapse Using RegulomeDB Annotations.BioMed research international · 2015Trial
- Expression level of matrix metalloproteinases -1, -2 and -9 associated with pelvic organ prolapse: experimental analytical study of round ligaments of Congolese women in two hospitals from the city of Kananga in Democratic Republic of Congo.The Pan African medical journal · 2025Article
- Review
- Genetics of Female Pelvic Organ Prolapse: Up to Date.Biomolecules · 2024Review
- Polymorphism and pelvic organ prolapse: combining strict inclusion criteria and environmental risk factors as a good standard for further studies.Gynecology and pelvic medicine · 2024Article
- The role of GZMA as a target of cysteine and biomarker in Alzheimer's disease, pelvic organ prolapse, and tumor progression.Frontiers in pharmacology · 2024Article
- Potential molecular targets for intervention in pelvic organ prolapse.Frontiers in medicine · 2023Review
- The polymorphisms of extracellular matrix-remodeling genes are associated with pelvic organ prolapse.International urogynecology journal · 2022Article
- Collagen type 1A1, type 3A1, and LOXL1/4 polymorphisms as risk factors of pelvic organ prolapse.BMC research notes · 2021Article
- Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population.Hereditas · 2020Article
- Identification of pelvic organ prolapse risk susceptibility gene SNP locus in Xinjiang women.International urogynecology journal · 2020Article
- Genetic association in female stress urinary incontinence based on proteomic findings: a case-control study.International urogynecology journal · 2020Article
- Study of the polymorphism rs3025058 of the MMP-3 gene and risk of pelvic organ prolapse in Brazilian women.European journal of obstetrics & gynecology and reproductive biology: X · 2019Article
- Klotho Protein Reduced the Expression of Matrix Metalloproteinase-1 (MMP-1) and Matrix Metalloproteinase-3 (MMP-3) in Fibroblasts from Patients with Pelvic Organ Prolapse (POP) by Down-Regulating the Phosphorylation of ERK1/2.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019Article
- Association between col1a2 Polymorphism and the Occurrence of Pelvic Organ Prolapse in Brazilian Women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019Article
- Matrix metalloproteinase-3 gene promoter polymorphisms: A potential risk factor for pelvic organ prolapse.Biomedical reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisTo investigate the associations between single nucleotide polymorphism (SNP) type 1G/2G at position -1607/-1608 of the matrix metalloproteinase (MMP)-1 gene and SNP type 5A/6A at position -1612/-1617 of the MMP-3 gene and the development of pelvic organ prolapse (POP) in women.
methods133 patients with symptomatic POP were included in the study group. The control group consisted of 132 women with a normal pelvic floor. 1G/2G MMP-1 and 5A/6A MMP-3 SNPs were determined by polymerase chain reaction (PCR) and restriction fragments length polymorphism analysis.
resultsWhen estimated individually none of the investigated SNPs were associated with POP. The combined MMP-1/MMP-3 SNP analysis showed that the following polymorphic pairs were overrepresented in women with POP: 1G/2G -5A/6A, 2G/2G -5A/6A, 2G/2G -5A/5A, 1G/1G -6A/6A, p=0.005.
conclusionsThe combined effect of -1607/-1608 MMP-1 and -1612/-1617 MMP-3 SNPs may contribute to the development of POP in some women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.