ArticleJournal of cell science2013
Sirtuin-3 modulates Bak- and Bax-dependent apoptosis.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Microvascular Rarefaction and Heart Failure With Preserved Ejection Fraction.Frontiers in cardiovascular medicine · 2019Review
- Mitochondrial CaJournal of bioenergetics and biomembranes · 2017Review
- Anion Channels of Mitochondria.Handbook of experimental pharmacology · 2017Review
- Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation.International journal of biological sciences · 2016Article
- Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.Cell death and differentiation · 2015Review
- {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.BioMed research international · 2015Article
- Mitochondrial and postmitochondrial survival signaling in cancer.Mitochondrion · 2014Review
- Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.Molecular cell · 2014Review
- The tangled circuitry of metabolism and apoptosis.Molecular cell · 2013Review
Corrections and comments
- Commented on by
- Commented on by
- Expression of concern
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sirtuin-3 exhibits properties of a tumor suppressor partly emanating from its ability to control the state of mitochondrial metabolism, with depletion of sirt-3 increasing tumor cell survival. In the present study we demonstrate that depletion of sirtuin-3 brings about an anti-apoptotic phenotype via stimulating cyclophilin-D activity, which promotes the binding of hexokinase II to the mitochondria, thereby preventing Bak/Bax dependent mitochondrial injury and cell death. By contrast, increased expression of sirtuin-3 decreases cyclophilin-D activity, resulting in detachment of hexokinase II from the mitochondria and potentiation of Bak- and Bax-induced mitochondrial injury and loss of cell viability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.