ArticleJournal of molecular neuroscience : MN2013
Changes in the BAG1 expression of Schwann cells after sciatic nerve crush.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury.Frontiers in neuroscience · 2017Review
- Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury.Cellular and molecular neurobiology · 2015Article
- Up-regulation of NF45 correlates with Schwann cell proliferation after sciatic nerve crush.Journal of molecular neuroscience : MN · 2015Article
- Article
- Upregulated expression of ebp1 contributes to schwann cell differentiation and migration after sciatic nerve crush.Journal of molecular neuroscience : MN · 2014Article
- Up-regulation of HDAC4 is associated with Schwann cell proliferation after sciatic nerve crush.Neurochemical research · 2014Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bcl-2-associated athanogene-1 (BAG1), a co-chaperone for Hsp70/Hsc70, is a multifunctional protein, which has been shown to suppress apoptosis and enhance neuronal differentiation. However, the expression and roles of BAG1 in peripheral system lesions and repair are still unknown. In this study, we investigated the dynamic changes in BAG1 expression in an acute sciatic nerve crush model in adult rats. Western blot analysis revealed that BAG1 was expressed in normal sciatic nerves. BAG1 expression increased progressively after sciatic nerve crush, reached a peak 2 weeks post-injury, and then returned to the normal level 4 weeks post-injury. Spatially, we observed that BAG1 was mainly expressed in Schwann cells and that BAG1 expression increased in Schwann cells after injury. In vitro, we found that BAG1 expression increased during the cyclic adenosine monophosphate (cAMP)-induced Schwann cell differentiation process. BAG1-specific siRNA inhibited cAMP-induced Schwann cell differentiation. In conclusion, we speculated that BAG1 was upregulated in the sciatic nerve after crush, which was associated with Schwann cell differentiation.
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