ArticleClinical and experimental medicine2014
High expression of TNF alpha is associated with -308 and -238 TNF alpha polymorphisms in knee osteoarthritis.
Article in Clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk.BMC musculoskeletal disorders · 2014Pooled it
- Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis.Arthritis research & therapy · 2012Pooled it
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- Macrophage migration inhibitory factor may play a protective role in osteoarthritis.Arthritis research & therapy · 2021Article
- Identification of key genes in osteoarthritis using bioinformatics, principal component analysis and meta-analysis.Experimental and therapeutic medicine · 2021Article
- Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.PloS one · 2021Article
- A study on the mechanism of Wnt inhibitory factor 1 in osteoarthritis.Archives of medical science : AMS · 2020Article
- Are There Any Common Genetic Risk Markers for Rheumatoid Arthritis and Periodontal Diseases? A Case-Control Study.Mediators of inflammation · 2019Article
- Association of cytokine gene polymorphisms with osteoarthritis susceptibility.Experimental and therapeutic medicine · 2018Article
- Association of TNF-α-308 G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis.Journal of orthopaedics · 2018Article
- Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- The single-nucleotide polymorphism (SNP) of tumor necrosis factor α -308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population.Clinical rheumatology · 2017Article
- Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals.Immunity & ageing : I & A · 2017Article
- TNF-α and MTHFR Polymorphisms Associated with Cerebral Palsy in Chinese Infants.Molecular neurobiology · 2016Article
- Mesenchymal stem-cell potential in cartilage repair: an update.Journal of cellular and molecular medicine · 2014Review
- Association analysis of two candidate polymorphisms in the tumour necrosis factor-α gene with osteoarthritis in a Chinese population.International orthopaedics · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee osteoarthritis (OA) is a common chronic degenerative disease characterized by the loss of articular cartilage components due to an imbalance between extracellular matrix destruction and repair. The proinflammatory cytokines involved in OA, TNFα and IL1β, are considered the major implicated. The aim of this study was to investigate the relationship between TNFα -308 and -238 polymorphisms with messenger RNA (mRNA) and soluble TNFα expression in knee OA patients and healthy subjects (HS). Case-control study involved 50 knee OA patients classified according to 1986 ACR Classification Criteria, as well as 100 HS. The Western Ontario and McMaster Universities Osteoarthritis Index and Lequesne disability index were applied to OA patients. The -308 and -238 polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism technique. The TNFα mRNA expression was quantified by real-time PCR using TaqMan method. The sTNFα levels were measured by enzyme-linked immunosorbent assay. The TNFα mRNA expression in knee OA patients was higher than in HS (1.56-fold). In addition, the TNFα mRNA expression was higher in carriers of G allele in the knee OA group for both polymorphisms. The sTNFα levels were increased in G/G versus G/A genotypes in both studied polymorphisms (p < 0.05). However, the TNFα -308 and -238 genotypes did not show statistical differences between groups. The G allele of TNFα -308 and -238 polymorphisms is associated with high mRNA and soluble expression in knee OA patients. However, it is not a marker of susceptibility in Western Mexico. Further studies are necessary to confirm these findings.
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