Evidence map›Paper›PMID 23108303›Full record

ReviewDigestive diseases (Basel, Switzerland)2012

Cellular immune suppressor mechanisms in patients with hepatocellular carcinoma.

Fei Zhao, Firouzeh Korangy, Tim F Greten

Open access · bronzeAbstract readReview
In one paragraph

Review in Digestive diseases (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Immunotherapy resistance of lung cancer.Cancer drug resistance (Alhambra, Calif.) · 2022
    Article
  4. Donor-derived regulatory dendritic cell infusion results in host cell cross-dressing and T cell subset changes in prospective living donor liver transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  5. [Immunotherapy for Lung Cancer: Mechanisms of Resistance and Response Strategy].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Mechanisms of hepatocellular carcinoma progression.World journal of gastroenterology · 2019
    Review
  11. Review
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fei ZhaoGastrointestinal Malignancy Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Firouzeh Korangy
Tim F Greten
Center for Cancer Research · USNational Cancer Institute · US

Funding

Immune suppressor mechanisms in patients with GI cancerZIABC011344 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GRETEN, TIM · 2010 to 2025
$2.2M
Intramural NIH HHS ZIA BC011344
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) has been shown to induce several immune suppressor mechanisms in patients. Our laboratory has been investigating different cellular mechanisms of immune suppression in patients with HCC. These suppressor mechanisms range from CD4(+) regulatory T cells, functionally impaired dendritic cells, neutrophils, and monocytes to myeloid-derived suppressor cells. In vitro as well as in vivo studies have demonstrated that abrogation of the suppressor cells enhances or unmasks tumor-specific anti-tumor immune responses. We performed a literature search for immune suppressor cells in HCC, and here we provide a comprehensive summary of the latest studies in this field.

Indexed as

Immune ToleranceImmunity, CellularCarcinoma, HepatocellularDendritic CellsHumansLiver NeoplasmsMonocytesNeutrophilsTh17 CellsT-Lymphocytes, RegulatoryTumor Escape

Identifiers

PMID23108303
PMCPMC3530892
OpenAlexW2016805395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.