ArticleJournal of leukocyte biology2013
Leukocytes regulate retinal capillary degeneration in the diabetic mouse via generation of leukotrienes.
Article in Journal of leukocyte biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 44 citations in OpenAlex.
- Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberine.Molecular vision · 2013Trial
- Theophylline Inhibits Capillary Degeneration in Early Diabetic Retinopathy.Investigative ophthalmology & visual science · 2026Article
- Lipoxin A4 (LXA4) as a Potential Drug for Diabetic Retinopathy.Medicina (Kaunas, Lithuania) · 2025Review
- Diabetes Modulates Iodothyronine Deiodinase 2 Expression in the Mouse Retina: A Role for Thyroid Hormone in the Pathogenesis of Diabetic Retinopathy.Investigative ophthalmology & visual science · 2023Article
- CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice.Diabetologia · 2023Article
- ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes.Diabetologia · 2022Article
- Article
- Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies.Molecular pharmacology · 2021Article
- Evidence on n-3 Fatty Acids and Oleic Acid Role in Retinal Inflammation and Microvascular Integrity: Insight from a Hyperlipidemic Rat Model.Inflammation · 2020Article
- Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy.PloS one · 2020Article
- Montelukast Prevents Early Diabetic Retinopathy in Mice.Diabetes · 2019Article
- Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy.Investigative ophthalmology & visual science · 2019Article
- Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research.Ophthalmic research · 2019Review
- Review
- Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy.Diabetes · 2018Article
- Do photoreceptor cells cause the development of retinal vascular disease?Vision research · 2017Review
- Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes.Diabetologia · 2017Article
- Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy.The American journal of pathology · 2017Review
- Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes.Investigative ophthalmology & visual science · 2016Article
- Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding the early pathogenesis of DR may uncover new therapeutic targets to prevent or slow the progression of this sight-threatening disorder. We investigated the role of leukocyte-mediated generation of LTs in regulation of retinal capillary degeneration and inflammation in the diabetic mouse. We generated (1) chimeric mice that lacked the ability to generate LTs by transplanting 5LO-/- bone marrow cells into ND.WT mice and into SD.WT mice and (2) "control" chimeric mice by transplanting WT bone marrow cells into 5LO-/- mice or into WT mice. Retinas from diabetic chimeric mice with WT marrow demonstrated capillary degeneration to the same extent as retinas from diabetic, nonchimeric WT mice. In contrast, retinas from diabetic chimeric mice with 5LO-/- marrow developed significantly less capillary degeneration and pericyte loss (P<0.05). In the retinas from chimeric mice with WT marrow, diabetes induced a rise in leukocyte adherence to the microvasculature, expression of the NF-κB p65 subunit, and ICAM1, superoxide generation, and retinal microvascular permeability, yet these characteristic responses were blunted by >50% in diabetic chimeras containing 5LO-/- leukocytes (P<0.05). Our data suggest the critical involvement of leukocytes and LTs in the regulation of inflammation and capillary degeneration in DR.
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Registered trials
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