ArticleFEBS letters2012
Signaling regulated endocytosis and exocytosis lead to mating pheromone concentration dependent morphologies in yeast.
Article in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Study of impacts of two types of cellular aging on the yeast bud morphogenesis.PLoS computational biology · 2024Article
- Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts.Nature communications · 2022Article
- Coordinating cell polarization and morphogenesis through mechanical feedback.PLoS computational biology · 2021Article
- Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.Molecular biology of the cell · 2018Article
- Mechanical feedback coordinates cell wall expansion and assembly in yeast mating morphogenesis.PLoS computational biology · 2018Article
- Exploring the inhibitory effect of membrane tension on cell polarization.PLoS computational biology · 2017Article
- Dynamics of cell wall elasticity pattern shapes the cell during yeast mating morphogenesis.Open biology · 2016Article
- Modelling of Yeast Mating Reveals Robustness Strategies for Cell-Cell Interactions.PLoS computational biology · 2016Article
- Alternative cell polarity behaviours arise from changes in G-protein spatial dynamics.IET systems biology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Polarized cell morphogenesis requires actin cytoskeleton rearrangement for polarized transport of proteins, organelles and secretory vesicles, which fundamentally underlies cell differentiation and behavior. During yeast mating, Saccharomyces cerevisiae responds to extracellular pheromone gradients by extending polarized projections, which are likely maintained through vesicle transport to (exocytosis) and from (endocytosis) the membrane. We experimentally demonstrate that the projection morphology is pheromone concentration-dependent, and propose the underlying mechanism through mathematical modeling. The inclusion of membrane flux and dynamically evolving cell boundary into our yeast mating signaling model shows good agreement with experimental measurements, and provides a plausible explanation for pheromone-induced cell morphology.
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Registered trials
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