ArticleAmerican journal of nephrology2012
Association between kidney function and telomere length: the heart and soul study.
Article in American journal of nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease.Nutrients · 2016Trial
- Hypertension and epigenetic aging: socio-biological pathways of health disparity.Clinical epigenetics · 2026Article
- Article
- Review
- Telomere Attrition in Chronic Kidney Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Tumor necrosis factor-alpha mediates the negative association between telomere length and kidney dysfunction.International journal of medical sciences · 2023Article
- How social/environmental determinants and inflammation affect salivary telomere length among middle-older adults in the health and retirement study.Scientific reports · 2022Article
- Association Between Baseline Buccal Telomere Length and Progression of Kidney Function: The Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Neck-to-height ratio is positively associated with diabetic kidney disease in Chinese patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2022Article
- Association of leukocyte telomere length with chronic kidney disease in East Asians with type 2 diabetes: a Mendelian randomization study.Clinical kidney journal · 2021Article
- Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans.BMC medical genomics · 2019Article
- Alcohol consumption and leukocyte telomere length.Scientific reports · 2019Article
- Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.Frontiers in genetics · 2019Review
- Peripheral Blood Leukocyte Telomere Length Is Associated with Age but Not Renal Function: A Cross-Sectional Follow-Up Study.The journal of nutrition, health & aging · 2018Article
- Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States.Oncotarget · 2017Article
- Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk.PloS one · 2017Article
- A Prospective Study Investigating Prediagnostic Leukocyte Telomere Length and Risk of Developing Rheumatoid Arthritis in Women.The Journal of rheumatology · 2016Article
- A Cross-Sectional Study of Ageing and Cardiovascular Function over the Baboon Lifespan.PloS one · 2016Article
- Association of relative telomere length with progression of chronic kidney disease in two cohorts: effect modification by smoking and diabetes.Scientific reports · 2015Article
- Select aging biomarkers based on telomere length and chronological age to build a biological age equation.Age (Dordrecht, Netherlands) · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTelomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening.
methodsThe Heart and Soul Study is a longitudinal study of patients with stable coronary heart disease. Measures of baseline kidney function included: serum creatinine, creatinine-derived estimated glomerular filtration rate (eGFR(CKD-EPI)), 24-hour urine measured creatinine clearance, cystatin C, cystatin C-derived estimated glomerular filtration rate (eGFRcys) and urine albumin to creatinine ratio. Telomere length was measured from peripheral blood leukocytes at baseline (n = 954) and 5 years later (n = 608). Linear regression models were used to test the association of kidney function with (i) baseline telomere length and (ii) change in telomere length over 5 years.
resultsAt baseline, mean eGFR(CKD-EPI) was 72.6 (±21.5) ml/min/1.73 m(2), eGFRcys was 71.0 (±23.1) ml/min/1.73 m(2) and ACR was 8.6 (±12.3) mg/g. Only lower baseline eGFR(CKD-EPI) was associated with shorter baseline telomere length (9.1 (95% CI 1.2-16.9) fewer base pairs for every 5 ml/min/1.73 m(2) lower eGFR(CKD-EPI)). Lower baseline eGFR(CKD-EPI) (and all other measures of kidney function) predicted more rapid telomere shortening (10.8 (95% CI 4.3-17.3) decrease in base pairs over 5 years for every 5 ml/min/1.73 m(2) lower eGFR(CKD-EPI)). After adjustment for age, these associations were no longer statistically significant.
conclusionsIn patients with coronary heart disease, reduced kidney function is associated with (i) shorter baseline telomere length and (ii) more rapid telomere shortening over 5 years; however, these associations are entirely explained by older age.
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