ArticleOphthalmology2013
Prevalence, treatment, and outcomes of coexistent ocular surface squamous neoplasia and pterygium.
Article in Ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- An evaluation of skin and eye diseases associated with exposure to solar ultraviolet radiation in Central Asia.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Pooled it
- Transcriptomics and network analysis highlight potential pathways in the pathogenesis of pterygium.Scientific reports · 2022Pooled it
- Exploring dysregulation of cuproptosis-related genes molecular clusters and candidate biomarkers in pterygium.Scientific reports · 2026Article
- Artificial Intelligence for Diagnostic Guidance in Ocular Surface Disorders.Journal of clinical medicine · 2026Review
- Accuracy of ChatGPT in differentiating ocular surface neoplasms using text-based summaries: a comparative analysis of pterygium, pseudopterygium, and CIN.International ophthalmology · 2026Article
- Enhanced Imaging of Ocular Surface Lesions.Journal of clinical medicine · 2025Review
- Can high-resolution optical coherence tomography provide an optical biopsy for ocular surface lesions?Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2025Review
- Update in the Diagnosis and Management of Ocular Surface Squamous Neoplasia (OSSN).Journal of clinical medicine · 2025Review
- Novel automated non-invasive detection of ocular surface squamous neoplasia using artificial intelligence.World journal of methodology · 2024Review
- Prevalence of co-existent neoplasia in clinically diagnosed pterygia in a UK population.Eye (London, England) · 2023Article
- The Management of Ocular Surface Squamous Neoplasia (OSSN).International journal of molecular sciences · 2022Review
- Article
- Spontaneous rupture of ocular surface squamous neoplasia-a case report.International journal of ophthalmology · 2022Article
- Pterygium-The Good, the Bad, and the Ugly.Cells · 2021Review
- Update on the Management of Ocular Surface Squamous Neoplasia.Current ophthalmology reports · 2021Article
- Clinical and Pathologic Presentation of Primary Ocular Surface Tumors among Zambians.Ocular oncology and pathology · 2021Article
- Synchronous eyelid oncocytoma and conjunctival intraepithelial neoplasia.Autopsy & case reports · 2021Article
- Frequency of conjunctival epithelial dysplasia in patients with pterygium.Arquivos brasileiros de oftalmologia · 2020Article
- Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review.International ophthalmology · 2020Article
- A novel role for Livin in the response to ultraviolet B radiation and pterygium development.International journal of molecular medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study was to determine the prevalence of ocular surface squamous neoplasia (OSSN) coexisting with pterygia in South Florida and to study the treatment and related outcomes.
designNoninterventional retrospective study.
participantsA total of 2005 patients with surgically excised pterygia at the Bascom Palmer Eye Institute from 2000 to 2010.
methodsPathology reports of patients with pterygia were reviewed for evidence of OSSN. Patients were divided into the following groups: pterygium and no OSSN (group 1), clinically suspected OSSN with pterygium (group 2), and unexpected OSSN with pterygium found on histopathology (group 3). Clinical charts of patients in groups 2 and 3 were reviewed.
main outcome measuresPeriod prevalence, treatment, and outcome.
resultsIn surgically excised pterygia, the prevalence of coexistent OSSN was 1.7% (n = 34), of which 41% (n = 14) were clinically suspected preoperatively (group 2) and 59% (n = 20) were unexpectedly found on histopathology (group 3). Clinically suspected OSSN with pterygia was generally treated with wide surgical margins and cryotherapy, whereas unexpected OSSN with pterygia was treated with simple excision, followed by adjuvant interferon treatment in 30% (n = 6). After a mean follow-up of 2 years, there were no recurrences in the suspected OSSN group and 2 recurrences in the unexpected OSSN group. The recurrence rate in the latter group was 11% at 1 year and 24% at 2 years.
conclusionsOcular surface squamous neoplasia is uncommonly found to coexist with pterygium. The prognosis in suspected OSSN cases is excellent, with no recurrences noted despite positive margins in 50% of cases. The recurrence rates of unexpected OSSN mirrors that of OSSN not associated with pterygium, and thus vigilance for recurrence is important.
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Registered trials
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