ArticleBMC genetics2012
Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples.
Article in BMC genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Article
- Unraveling structural and conformational dynamics of DGAT1 missense nsSNPs in dairy cattle.Scientific reports · 2022Article
- Genome-wide association study of beef bull semen attributes.BMC genomics · 2022Article
- Direct Phenotyping and Principal Component Analysis of Type Traits Implicate Novel QTL in Bovine Mastitis through Genome-Wide Association.Animals : an open access journal from MDPI · 2021Article
- Genome-wide association study on Fourier transform infrared milk spectra for two Danish dairy cattle breeds.BMC genetics · 2020Article
- Article
- Genome-Wide Association Study for Milk Fatty Acids in Holstein Cattle Accounting for theAnimals : an open access journal from MDPI · 2019Article
- Reliability of genomic prediction for milk fatty acid composition by using a multi-population reference and incorporating GWAS results.Genetics, selection, evolution : GSE · 2019Article
- Multi-population GWAS and enrichment analyses reveal novel genomic regions and promising candidate genes underlying bovine milk fatty acid composition.BMC genomics · 2019Article
- Fine-mapping sequence mutations with a major effect on oligosaccharide content in bovine milk.Scientific reports · 2019Article
- Integrated PTR-ToF-MS, GWAS and biological pathway analyses reveal the contribution of cow's genome to cheese volatilome.Scientific reports · 2018Article
- Role of Fatty Acids in Milk Fat and the Influence of Selected Factors on Their Variability-A Review.Molecules (Basel, Switzerland) · 2018Review
- SNP co-association and network analyses identify E2F3, KDM5A and BACH2 as key regulators of the bovine milk fatty acid profile.Scientific reports · 2017Article
- Seasonal Variation of Triacylglycerol Profile of Bovine Milk.Metabolites · 2017Article
- A genome scan for milk production traits in dairy goats reveals two new mutations in Dgat1 reducing milk fat content.Scientific reports · 2017Article
- High density genome wide genotyping-by-sequencing and association identifies common and low frequency SNPs, and novel candidate genes influencing cow milk traits.Scientific reports · 2016Article
- Article
- Prospecting major genes in dairy buffaloes.BMC genomics · 2015Article
- A genome-wide association study reveals dominance effects on number of teats in pigs.PloS one · 2014Article
- Genomic adaptation of admixed dairy cattle in East Africa.Frontiers in genetics · 2014Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this study we perform a genome-wide association study (GWAS) for bovine milk fatty acids from summer milk samples. This study replicates a previous study where we performed a GWAS for bovine milk fatty acids based on winter milk samples from the same population. Fatty acids from summer and winter milk are genetically similar traits and we therefore compare the regions detected in summer milk to the regions previously detected in winter milk GWAS to discover regions that explain genetic variation in both summer and winter milk.
resultsThe GWAS of summer milk samples resulted in 51 regions associated with one or more milk fatty acids. Results are in agreement with most associations that were previously detected in a GWAS of fatty acids from winter milk samples, including eight 'new' regions that were not considered in the individual studies. The high correlation between the -log10(P-values) and effects of SNPs that were found significant in both GWAS imply that the effects of the SNPs were similar on winter and summer milk fatty acids.
conclusionsThe GWAS of fatty acids based on summer milk samples was in agreement with most of the associations detected in the GWAS of fatty acids based on winter milk samples. Associations that were in agreement between both GWAS are more likely to be involved in fatty acid synthesis compared to regions detected in only one GWAS and are therefore worthwhile to pursue in fine-mapping studies.
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