ArticleCortex; a journal devoted to the study of the nervous system and behavior
Mentalising music in frontotemporal dementia.
Article in Cortex; a journal devoted to the study of the nervous system and behavior. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Evaluation of Discriminative Detection Abilities of Social Cognition Measures for the Diagnosis of the Behavioral Variant of Frontotemporal Dementia: a Systematic Review.Neuropsychology review · 2021Pooled it
- Music processing in behavioural variant frontotemporal dementia and Alzheimer's disease: a functional MRI study.Brain communications · 2026Article
- Functional neuroanatomy of musical object processing in Alzheimer's disease and frontotemporal dementia.Brain communications · 2026Article
- International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative.Alzheimer's research & therapy · 2025Article
- Musicality and social cognition in dementia: clinical and anatomical associations.Brain communications · 2024Article
- Developing a music-based digital therapeutic to help manage the neuropsychiatric symptoms of dementia.Frontiers in digital health · 2023Article
- Music appreciation phenotypes in patients with frontotemporal dementia: A pilot study.International journal of geriatric psychiatry · 2022Article
- Measuring social cognition in frontotemporal lobar degeneration: a clinical approach.Journal of neurology · 2022Review
- Laughter as a paradigm of socio-emotional signal processing in dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- The functional neuroanatomy of emotion processing in frontotemporal dementias.Brain : a journal of neurology · 2019Article
- Cognitive impairment in substance use disorders.CNS spectrums · 2019Article
- Increased Functional Connectivity of the Angular Gyrus During Imagined Music Performance.Frontiers in human neuroscience · 2019Article
- Music models aberrant rule decoding and reward valuation in dementia.Social cognitive and affective neuroscience · 2018Article
- Functional dissociation between anterior temporal lobe and inferior frontal gyrus in the processing of dynamic body expressions: Insights from behavioral variant frontotemporal dementia.Human brain mapping · 2016Article
- Processing emotion from abstract art in frontotemporal lobar degeneration.Neuropsychologia · 2016Article
- Humour processing in frontotemporal lobar degeneration: A behavioural and neuroanatomical analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2015Article
- Brain disorders and the biological role of music.Social cognitive and affective neuroscience · 2015Review
- Functional MRI of music emotion processing in frontotemporal dementia.Annals of the New York Academy of Sciences · 2015Article
- Music and literature: are there shared empathy and predictive mechanisms underlying their affective impact?Frontiers in psychology · 2015Article
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Authors and funding
8 authors.
Funding
Abstract
Despite considerable recent interest, the biological basis and clinical diagnosis of behavioural variant frontotemporal dementia (bvFTD) pose unresolved problems. Mentalising (the cognitive capacity to interpret the behaviour of oneself and others in terms of mental states) is impaired as a prominent feature of bvFTD, consistent with involvement of brain regions including ventro-medial prefrontal cortex (PFC), orbitofrontal cortex and anterior temporal lobes. Here, we investigated mentalising ability in a cohort of patients with bvFTD using a novel modality: music. We constructed a novel neuropsychological battery requiring attribution of affective mental or non-mental associations to musical stimuli. Mentalising performance of patients with bvFTD (n = 20) was assessed in relation to matched healthy control subjects (n = 20); patients also had a comprehensive assessment of behaviour and general neuropsychological functions. Neuroanatomical correlates of performance on the experimental tasks were investigated using voxel-based morphometry of patients' brain magnetic resonance imaging (MRI) scans. Compared to healthy control subjects, patients showed impaired ability to attribute mental states but not non-mental characteristics to music, and this deficit correlated with performance on a standard test of social inference and with carer ratings of patients' empathic capacity, but not with other potentially relevant measures of general neuropsychological function. Mentalising performance in the bvFTD group was associated with grey matter changes in anterior temporal lobe and ventro-medial PFC. These findings suggest that music can represent surrogate mental states and the ability to construct such mental representations is impaired in bvFTD, with potential implications for our understanding of the biology of bvFTD and human social cognition more broadly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.