ArticleMolecular brain2012
Control of directional change after mechanical stimulation in Drosophila.
Article in Molecular brain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Mechanically evoked spike responses of pentascolopidial chordotonal organs of Drosophila melanogaster larvae.The Journal of experimental biology · 2024Article
- First transcriptome profiling of D. melanogaster after development in a deep underground low radiation background laboratory.PloS one · 2021Article
- Modelling the mechanics of exploration in larval Drosophila.PLoS computational biology · 2019Article
- Glial CaeLife · 2019Article
- Injury-induced cold sensitization in Drosophila larvae involves behavioral shifts that require the TRP channel Brv1.PloS one · 2018Article
- Pervasive Behavioral Effects of MicroRNA Regulation inGenetics · 2017Article
- Turtle interacts with borderless in regulating glial extension and axon ensheathment.Molecular brain · 2017Article
- Novel Assay for Cold Nociception in Drosophila Larvae.Journal of visualized experiments : JoVE · 2017Article
- The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila.Current biology : CB · 2016Article
- Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour.Nature · 2016Article
- Aggression and social experience: genetic analysis of visual circuit activity in the control of aggressiveness in Drosophila.Molecular brain · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundProper adjustment of moving direction after external mechanical stimulation is essential for animals to avoid danger (e.g. predators), and thus is vital for survival. This process involves sensory inputs, central processing and motor outputs. Recent studies have made considerable progress in identifying mechanosensitive neurons and mechanosensation receptor proteins. Our understandings of molecular and cellular mechanisms that link mechanosensation with the changes in moving direction, however, remain limited.
resultsIn this study, we investigate the control of movement adjustment in Drosophila. In response to gentle touch at the anterior segments, Drosophila larvae reorient and select a new direction for forward movement. The extent of change in moving direction is correlated with the intensity of tactile stimuli. Sensation of gentle touch requires chordotonal organs and class IV da neurons. Genetic analysis indicates an important role for the evolutionarily conserved immunoglobulin (Ig) superfamily protein Turtle (Tutl) to regulate touch-initiated directional change. Tutl is required specifically in post-mitotic neurons at larval stage after the completion of embryonic development. Circuit breaking analysis identified a small subset of Tutl-positive neurons that are involved in the adjustment of moving direction.
conclusionWe identify Tutl and a small subset of CNS neurons in modulating directional change in response to gentle touch. This study presents an excellent starting point for further dissection of molecular and cellular mechanisms controlling directional adjustment after mechanical stimulation.
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