Trial reportAddiction (Abingdon, England)2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Trial report in Addiction (Abingdon, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04251208 (MOms in REcovery), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Guideline
- Mindful moms: acceptability and impact of co-designed and digitally delivered video meditations for pregnant and parenting women with opioid use disorder.Annals of medicine · 2025Trial
- Impact of Depressive Symptom Severity on Buprenorphine/Naloxone and Methadone Outcomes in People With Prescription-Type Opioid Use Disorder: Results From a Pragmatic Randomized Controlled Trial.Journal of dual diagnosisTrial
- Factors associated with reduced substance use and treatment completion among justice-involved pregnant women.Frontiers in psychiatry · 2026Article
- Prenatal substance use and mental health comorbidities predict continued use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Article
- Co-occurring illicit fentanyl use and psychiatric disorders in emergency department patients.Scientific reports · 2025Article
- Factors associated with medications for opioid use disorder (MOUD) treatment success during the pregnancy and postpartum periods: A scoping review.Drug and alcohol dependence · 2024Article
- Services for perinatal patients with opioid use disorder: a comprehensive Baltimore City-wide 2023 assessment.Addiction science & clinical practice · 2024Article
- Fostering Hope: Comprehensive Accessible Mother-Infant Dyad Care for Neonatal Abstinence (CAIN).Children (Basel, Switzerland) · 2022Article
- Article
- Non-pharmacologic interventions to improve depression and anxiety among pregnant and parenting women who use substances: An integrative literature review.Drug and alcohol dependence reports · 2022Review
- Methadone and buprenorphine discontinuation among postpartum women with opioid use disorder.American journal of obstetrics and gynecology · 2021Article
- Addiction treatment in the postpartum period: an opportunity for evidence-based personalized medicine.International review of psychiatry (Abingdon, England) · 2021Review
- Improved Maternal and Infant Outcomes with Serial, Self-Reported Early Prenatal Substance Use Screening.Maternal and child health journal · 2021Article
- Anxiety, depression, and opioid misuse among adults with chronic pain: the role of emotion dysregulation.Journal of behavioral medicine · 2021Article
- A life-course theory exploration of opioid-related maternal mortality in the United States.Addiction (Abingdon, England) · 2020Article
- Buprenorphine dosing for the treatment of opioid use disorder through pregnancy and postpartum.Current treatment options in psychiatry · 2020Article
- Maternal and infant characteristics associated with maternal opioid overdose in the year following delivery.Addiction (Abingdon, England) · 2020Article
- Factors associated with treatment retention in pregnant women with opioid use disorders prescribed methadone or electing non-pharmacological treatment.Women & health · 2020Article
- Comorbidity of opioid-related and anxiety-related symptoms and disorders.Current opinion in psychology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
aimsTo examine the relationship of anxiety and depression symptoms with treatment outcomes (treatment discontinuation, rates of ongoing use of illicit drugs and likelihood of preterm delivery) in opioid-dependent pregnant women and describe their use of psychotropic medications. DESIGN AND
settingSecondary data analysis from a randomized clinical trial of treatment for opioid dependence during pregnancy.
participantsA total of 175 opioid-dependent pregnant women, of whom 131 completed treatment. MEASUREMENTS: Symptoms of anxiety and depression were captured with the 15-item Mini International Neuropsychiatric Interview (MINI) screen. Use of illicit drugs was measured by urine drug screening. Preterm delivery was defined as delivery prior to 37 weeks' gestation. Self-reported use of concomitant psychotropic medication at any point during the study was recorded.
findingsWomen reporting only anxiety symptoms at study entry were more likely to discontinue treatment [adjusted odds ratio (OR) = 4.56, 95% confidence interval (CI) : 1.91-13.26, P = 0.012], while those reporting only depression symptoms were less likely to discontinue treatment (adjusted OR = 0.14, 95% CI : 0.20-0.88, P = 0.036) compared to women who reported neither depression nor anxiety symptoms. No statistically significant between-group differences were observed for ongoing illicit drug use or preterm delivery. A majority (61.4%) of women reported use of concomitant psychotropic medication at some point during study participation.
conclusionsOpioid agonist-treated pregnant patients with co-occurring symptoms of anxiety require additional clinical resources to prevent premature discontinuation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.