Trial reportAddiction (Abingdon, England)2012
Fetal assessment before and after dosing with buprenorphine or methadone.
Trial report in Addiction (Abingdon, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Impact of prenatal opioids on cardiac and autonomic development: systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2023Pooled it
- Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.Addiction (Abingdon, England) · 2016Pooled it
- Effects of an attachment-based intervention on autonomic regulation among opioid-exposed infants.Developmental psychobiology · 2022Trial
- Gestational Opioid Exposure: From Morphine to MOUD - How Opioids Impact Offspring Development and Maternal Care.Current topics in behavioral neurosciences · 2025Review
- Effects of prenatal opioid exposure on infant sympathetic and parasympathetic nervous system activity.Psychophysiology · 2024Article
- Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study.Drug safety · 2023Article
- Opioid, methamphetamine, and polysubstance use: perinatal outcomes for the mother and infant.Frontiers in pediatrics · 2023Review
- Antenatal interventions based upon fetal surveillance of the daily opioid-exposed fetus: a descriptive analysis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2020Article
- Article
- Opioid use disorder in pregnancy.The mental health clinician · 2019Article
- Differences in hospital length of stay between neonates exposed to buprenorphine versus methadone in utero: A retrospective chart review.Paediatrics & child health · 2019Article
- Beyond the Finnegan scoring system: Novel assessment and diagnostic techniques for the opioid-exposed infant.Seminars in fetal & neonatal medicine · 2019Review
- Fetal assessment in buprenorphine-maintained women using fetal magnetoencephalography: a pilot study.Addiction (Abingdon, England) · 2018Article
- Maternal buprenorphine treatment and fetal neurobehavioral development.American journal of obstetrics and gynecology · 2017Article
- Review
- Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers.American journal of obstetrics and gynecology · 2014Article
- Buprenorphine use in pregnant opioid users: a critical review.CNS drugs · 2013Review
- Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.Addiction (Abingdon, England) · 2012Review
- Review
- Comparing methadone and buprenorphine maintenance with methadone-assisted withdrawal for the treatment of opioid dependence during pregnancy: maternal and neonatal outcomes.Substance abuse and rehabilitation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
Abstract
aimTo determine pre- and post-dosing effects of prenatal methadone compared to buprenorphine on fetal wellbeing.
designA secondary analysis of data derived from the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a double-blind, double-dummy, randomized clinical trial.
settingSix United States sites and one European site that provided comprehensive opioid-dependence treatment to pregnant women.
participantsEighty-one of the 131 opioid-dependent pregnant women completing the MOTHER clinical trial, assessed between 31 and 33 weeks of gestation. MEASUREMENTS: Two fetal assessments were conducted, once before and once after study medication dosing. Measures included mean fetal heart rate (FHR), number of FHR accelerations, FHR reactivity in the fetal non-stress test (NST) and biophysical profile (BPP) score.
findingsSignificant group differences were found for number of FHR accelerations, non-reactive NST and BPP scores (all Ps < 0.05). There were no significant group differences before time of dosing. Significant decreases (all Ps < 0.05) occurred from pre- to post-dose assessment for mean FHR, FHR accelerations, reactive NST and fetal movement. The decrease in accelerations and reactive NST were significant only for fetuses in the methadone group, and this resulted in a significantly lower likelihood of a reactive NST compared to fetuses in the buprenorphine group.
conclusionBuprenorphine compared with methadone appears to result in less suppression of mean fetal heart rate, fetal heart rate reactivity and the biophysical profile score after medication dosing and these findings provide support for the relative safety of buprenorphine when fetal indices are considered as part of the complete risk-benefit ratio.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.