Trial reportAddiction (Abingdon, England)2012
Maternal Opioid Treatment: Human Experimental Research (MOTHER)--approach, issues and lessons learned.
Trial report in Addiction (Abingdon, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maintenance agonist treatments for opiate-dependent pregnant women.The Cochrane database of systematic reviews · 2020Pooled it
- Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes.Drug and alcohol dependence · 2018Trial
- Neonatal outcomes and their relationship to maternal buprenorphine dose during pregnancy.Drug and alcohol dependence · 2014Trial
- Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.Drug and alcohol dependence · 2013Trial
- Cigarette smoking in opioid-dependent pregnant women: neonatal and maternal outcomes.Drug and alcohol dependence · 2013Trial
- Fetal assessment before and after dosing with buprenorphine or methadone.Addiction (Abingdon, England) · 2012Trial
- Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication.Addiction (Abingdon, England) · 2012Trial
- Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.Addiction (Abingdon, England) · 2012Trial
- Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates.Addiction (Abingdon, England) · 2012Trial
- The relationship between maternal methadone dose at delivery and neonatal outcome: methodological and design considerations.Neurotoxicology and teratologyTrial
- Trends in Opioid Agonist Treatment for Opioid Dependence During Pregnancy: A Population-Based Study in New South Wales 2005-2021.Drug and alcohol review · 2026Article
- Protocol Commentary for the SUCCESS (Successful Recruitment and Retention in a Randomized Controlled Trial of Pregnant Participants with Opioid Use Disorder) Study.Substance use & addiction journal · 2025Article
- Buprenorphine maintenance treatment and its outcome among opioid dependent pregnant women: A case series from India.Indian journal of psychiatry · 2025Article
- The Impact of a Prenatal Education Program for Opioid-Dependent Mothers on Breastfeeding Rates of Infants at Risk for Neonatal Abstinence Syndrome.Advances in therapy · 2022Article
- Opioid use disorder in pregnancy: leveraging provider perceptions to inform comprehensive treatment.BMC health services research · 2021Article
- Early Environmental Exposures and Contaminants: a Design Framework for Biospecimen Collection and Analysis for a Prospective National Birth Cohort.Adversity and resilience science · 2020Article
- Substance use disorders and risk of severe maternal morbidity in the United States.Drug and alcohol dependence · 2020Article
- Adverse neonatal outcomes associated with maternal severe mental health diagnoses and opioid use.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Medication treatment for opioid use disorder in expectant mothers (MOMs): Design considerations for a pragmatic randomized trial comparing extended-release and daily buprenorphine formulations.Contemporary clinical trials · 2020Article
- Five-Year Outcomes Among Medicaid-Enrolled Children With In Utero Opioid Exposure.Health affairs (Project Hope) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
aimsThe Maternal Opioid Treatment: Human Experimental Research (MOTHER) project, an eight-site randomized, double-blind, double-dummy, flexible-dosing, parallel-group clinical trial is described. This study is the most current--and single most comprehensive--research effort to investigate the safety and efficacy of maternal and prenatal exposure to methadone and buprenorphine.
methodsThe MOTHER study design is outlined, and its basic features are presented.
conclusionsAt least seven important lessons have been learned from the MOTHER study: (i) an interdisciplinary focus improves the design and methods of a randomized clinical trial; (ii) multiple sites in a clinical trial present continuing challenges to the investigative team due to variations in recruitment, patient populations and hospital practices that, in turn, differentially impact recruitment rates, treatment compliance and attrition; (iii) study design and protocols must be flexible in order to meet the unforeseen demands of both research and clinical management; (iv) staff turnover needs to be addressed with a proactive focus on both hiring and training; (v) the implementation of a protocol for the treatment of a particular disorder may identify important ancillary clinical issues worthy of investigation; (vi) timely tracking of data in a multi-site trial is both demanding and unforgiving; and (vii) complex multi-site trials pose unanticipated challenges that complicate the choice of statistical methods, thereby placing added demands on investigators to effectively communicate their results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.