ReviewAddiction (Abingdon, England)2012
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Review in Addiction (Abingdon, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 69 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.
MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants
Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Maintenance agonist treatments for opiate-dependent pregnant women.The Cochrane database of systematic reviews · 2020Pooled it
- Clinical guideline for homeless and vulnerably housed people, and people with lived homelessness experience.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Guideline
- Pooled it
- Guideline
- Collaborative care programs for pregnant and postpartum individuals with opioid use disorder: Organizational characteristics of sites participating in the NIDA CTN0080 MOMs study.Journal of substance use and addiction treatment · 2023Trial
- Neonatal outcomes and their relationship to maternal buprenorphine dose during pregnancy.Drug and alcohol dependence · 2014Trial
- Maternal Opioid Treatment: Human Experimental Research (MOTHER)--approach, issues and lessons learned.Addiction (Abingdon, England) · 2012Trial
- Adolescent prefrontal and amygdala molecular signatures of perinatal morphine versus buprenorphine exposure in mice.Neurotoxicology · 2026Article
- Medication for opioid use disorder service delivery in carceral facilities: update and summary report.Health & justice · 2025Review
- Beyond a simple cause and effect relationship: Exploring the long-term outcomes of children prenatally exposed to opioids and other substances.Seminars in perinatology · 2025Review
- Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice.Neurotoxicology · 2023Article
- Self-Identified Stage in Recovery and Substance-Use Behaviors among Pregnant and Postpartum Women and People with Opioid Use Disorder.Healthcare (Basel, Switzerland) · 2023Article
- Neonatal Abstinence Syndrome in Infants with Prenatal Exposure to Methadone versus Buprenorphine.Children (Basel, Switzerland) · 2023Article
- The Influence of Mediators on the Relationship Between Antenatal Opioid Agonist Exposure and the Severity of Neonatal Opioid Withdrawal Syndrome.Maternal and child health journal · 2023Article
- Safety and Efficacy of Buprenorphine-Naloxone in Pregnancy: A Systematic Review of the Literature.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Review
- Intrauterine and Neonatal Exposure to Opioids: Toxicological, Clinical, and Medico-Legal Issues.Toxics · 2023Review
- Opioid, methamphetamine, and polysubstance use: perinatal outcomes for the mother and infant.Frontiers in pediatrics · 2023Review
- Development of a clinical and translational research curriculum for undergraduate students.Journal of clinical and translational science · 2023Article
- Development and Implementation of State and Federal Child Welfare Laws Related to Drug Use in Pregnancy.The Milbank quarterly · 2022Article
- Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.The New England journal of medicine · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 3 countries.
Funding
Abstract
aimsThis paper reviews the published literature regarding outcomes following maternal treatment with buprenorphine in five areas: maternal efficacy, fetal effects, neonatal effects, effects on breast milk and longer-term developmental effects.
methodsWithin each outcome area, findings are summarized first for the three randomized clinical trials and then for the 44 non-randomized studies (i.e. prospective studies, case reports and series and retrospective chart reviews), only 28 of which involve independent samples.
resultsResults indicate that maternal treatment with buprenorphine has comparable efficacy to methadone, although difficulties may exist with current buprenorphine induction methods. The available fetal data suggest buprenorphine results in less physiological suppression of fetal heart rate and movements than methadone. Regarding neonatal effects, perhaps the single definitive conclusion is that prenatal buprenorphine treatment results in a clinically significant less severe neonatal abstinence syndrome (NAS) than treatment with methadone. The limited research suggests that, like methadone, buprenorphine is compatible with breastfeeding. Data available thus far suggest that there are no deleterious effects of in utero buprenorphine exposure on infant development.
conclusionsWhile buprenorphine produces a less severe neonatal abstinence syndrome than methadone, both methadone and buprenorphine are important parts of a complete comprehensive treatment approach for opioid-dependent pregnant women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.