ArticleEvolution; international journal of organic evolution2012
Genomic basis of aging and life-history evolution in Drosophila melanogaster.
Article in Evolution; international journal of organic evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.
- Meta-analysis suggests the microbiome responds to Evolve and Resequence experiments in Drosophila melanogaster.BMC microbiology · 2021Pooled it
- Beyond fixation: persistent genetic variation under intense selection.Molecular biology and evolution · 2026Article
- Beyond Fixation: Persistent Genetic Variation Under Intense Selection.bioRxiv : the preprint server for biology · 2026Article
- Rapid Genomic Adaptation of Drosophila Melanogaster to Wolbachia Elimination.Microbial ecology · 2026Article
- Parallel adaptive responses to postponed reproduction increase lifespan and immune defense.bioRxiv : the preprint server for biology · 2026Article
- Systems genetics of lifespan and senescence in Drosophila melanogaster.BMC biology · 2025Article
- Effects of aging on gene expression networks in the Drosophila genetic reference panel.Cell reports · 2025Article
- Genomewide architecture of adaptation in experimentally evolvedJournal of genetics · 2024Article
- Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response.PLoS genetics · 2023Article
- Polygenic adaptation to overnutrition reveals a role for cholinergic signaling in longevity.bioRxiv : the preprint server for biology · 2023Article
- A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.Molecular biology and evolution · 2023Article
- Experimental Life History Evolution Results in Sex-specific Evolution of Gene Expression in Seed Beetles.Genome biology and evolution · 2023Article
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- Natural alleles at theProceedings. Biological sciences · 2022Article
- Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory EvolvedInternational journal of molecular sciences · 2022Article
- Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population.International journal of molecular sciences · 2021Review
- The Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila.Molecular biology and evolution · 2021Article
- Transposable Element Landscape in Drosophila Populations Selected for Longevity.Genome biology and evolution · 2021Article
- Article
- Detecting selected haplotype blocks in evolve and resequence experiments.Molecular ecology resources · 2021Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Natural diversity in aging and other life-history patterns is a hallmark of organismal variation. Related species, populations, and individuals within populations show genetically based variation in life span and other aspects of age-related performance. Population differences are especially informative because these differences can be large relative to within-population variation and because they occur in organisms with otherwise similar genomes. We used experimental evolution to produce populations divergent for life span and late-age fertility and then used deep genome sequencing to detect sequence variants with nucleotide-level resolution. Several genes and genome regions showed strong signatures of selection, and the same regions were implicated in independent comparisons, suggesting that the same alleles were selected in replicate lines. Genes related to oogenesis, immunity, and protein degradation were implicated as important modifiers of late-life performance. Expression profiling and functional annotation narrowed the list of strong candidate genes to 38, most of which are novel candidates for regulating aging. Life span and early age fecundity were negatively correlated among populations; therefore, the alleles we identified also are candidate regulators of a major life-history trade-off. More generally, we argue that hitchhiking mapping can be a powerful tool for uncovering the molecular bases of quantitative genetic variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.