ArticleACS nano2012
Probing of the assembly structure and dynamics within nanoparticles during interaction with blood proteins.
Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Chemical and Biological Determinants of PEG-Lipid Shedding From Therapeutic Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Chemical conjugation mitigates immunotoxicity of chemotherapy via reducing receptor-mediated drug leakage from lipid nanoparticles.Science advances · 2024Article
- Article
- FRET Ratiometric Nanoprobes for Nanoparticle Monitoring.Biosensors · 2021Review
- 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications.Stem cells international · 2021Review
- A redox-sensitive core-crosslinked nanosystem combined with ultrasound for enhanced deep penetration of nanodiamonds into tumors.RSC advances · 2020Article
- Toward understanding polymer micelle stability: Density ultracentrifugation offers insight into polymer micelle stability in human fluids.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Gelatin-hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR): Preparation, assessment of the physicochemical properties and the effect on mesenchymal stem cells.Journal of advanced periodontology & implant dentistry · 2020Article
- Förster Resonance Energy Transfer-Based Stability Assessment of PLGA Nanoparticles in Vitro and in Vivo.ACS applied bio materials · 2019Article
- Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer.Nano letters · 2018Article
- Article
- Novel redox-responsive polymeric magnetosomes with tunable magnetic resonance property forAdvanced functional materials · 2018Article
- Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines.Scientific reports · 2017Article
- Extremely long tumor retention, multi-responsive boronate crosslinked micelles with superior therapeutic efficacy for ovarian cancer.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Article
- Integrity of lipid nanocarriers in bloodstream and tumor quantified by near-infrared ratiometric FRET imaging in living mice.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines.Beilstein journal of organic chemistry · 2016Article
- Enhanced tumor delivery and antitumor response of doxorubicin-loaded albumin nanoparticles formulated based on a Schiff base.International journal of nanomedicine · 2016Article
- A smart and versatile theranostic nanomedicine platform based on nanoporphyrin.Nature communications · 2014Article
- Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers.Advanced drug delivery reviews · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Fully understanding the influence of blood proteins on the assembly structure and dynamics within nanoparticles is difficult because of the complexity of the system and the difficulty in probing the diverse elements and milieus involved. Here we show the use of site-specific labeling with spin probes and fluorophores combined with electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET) measurements to provide insights into the molecular architecture and dynamics within nanoparticles. These tools are especially useful for determining nanoparticle stability in the context of blood proteins and lipoproteins and have allowed us to quantitatively analyze the dynamic changes in assembly structure, local stability, and cargo diffusion of a class of novel telodendrimer-based micellar nanoparticles. When combined with human plasma and individual plasma components, we find that non-cross-linked nanoparticles immediately lose their original assembly structure and release their payload upon interaction with lipoproteins. In contrast, serum albumins and immunoglobulin gamma have moderate affects on the integrity of the nanoparticles. Disulfide cross-linked nanoparticles show minimal interaction with lipoproteins and can better retain their assembly structure and payload in vitro and in vivo. We further demonstrate how the enhanced stability and release property of disulfide cross-linked nanoparticles can be reversed in reductive conditions. These findings identify factors that are crucial to the performance of nanomedicines and provide design modes to control their interplay with blood factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.