ArticleFEMS microbiology letters2013
Escherichia coli glutathionylspermidine synthetase/amidase: phylogeny and effect on regulation of gene expression.
Article in FEMS microbiology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype.PLoS genetics · 2026Article
- Plant Beneficial Deep-Sea Actinobacterium,Biology · 2022Article
- PaeA (YtfL) protects from cadaverine and putrescine stress in Salmonella Typhimurium and E. coli.Molecular microbiology · 2021Article
- Effect of Spermidine on Biofilm Formation in Escherichia coli K-12.Journal of bacteriology · 2021Article
- Polyamines in protozoan pathogens.The Journal of biological chemistry · 2018Review
- Introduction to the Thematic Minireview Series: Sixty plus years of polyamine research.The Journal of biological chemistry · 2018Review
- Metabolic profiles of cysteine, methionine, glutamate, glutamine, arginine, aspartate, asparagine, alanine and glutathione in Streptococcus thermophilus during pH-controlled batch fermentations.Scientific reports · 2018Article
- Stationary-phase genes upregulated by polyamines are responsible for the formation of Escherichia coli persister cells tolerant to netilmicin.FEMS microbiology letters · 2017Article
- Polyamines Stimulate the Level of the σ38 Subunit (RpoS) of Escherichia coli RNA Polymerase, Resulting in the Induction of the Glutamate Decarboxylase-dependent Acid Response System via the gadE Regulon.The Journal of biological chemistry · 2015Article
- Glutathionylspermidine in the modification of protein SH groups: the enzymology and its application to study protein glutathionylation.Molecules (Basel, Switzerland) · 2015Review
- A predictor for predicting Escherichia coli transcriptome and the effects of gene perturbations.BMC bioinformatics · 2014Article
- Polyamines are critical for the induction of the glutamate decarboxylase-dependent acid resistance system in Escherichia coli.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Glutathionylspermidine synthetase/amidase (Gss) and the encoding gene (gss) have only been studied in Escherichia coli and several members of the Kinetoplastida phyla. In the present article, we have studied the phylogenetic distribution of Gss and have found that Gss sequences are largely limited to certain bacteria and Kinetoplastids and are absent in a variety of invertebrate and vertebrate species, Archea, plants, and some Eubacteria. It is striking that almost all of the 75 Enterobacteria species that have been sequenced contain sequences with very high degree of homology to the E. coli Gss protein. To find out the physiological significance of glutathionylspermidine in E. coli, we have performed global transcriptome analyses. The microarray studies comparing gss(+) and Δgss strains of E. coli show that a large number of genes are either up-regulated (76 genes more than threefold) or down-regulated (35 genes more than threefold) by the loss of the gss gene. Most significant categories of up-regulated genes include sulfur utilization, glutamine and succinate metabolism, polyamine and arginine metabolism, and purine and pyrimidine metabolism.
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Registered trials
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