ArticleRadiation research2012
Covalently linked tandem lesions in DNA.
Article in Radiation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Article
- Photochemical and Single Electron Transfer Generation of 2'-Deoxycytidin-The Journal of organic chemistry · 2023Article
- Mutagenic Effects of a 2-Deoxyribonolactone-Thymine Glycol Tandem DNA Lesion in Human Cells.Biochemistry · 2020Article
- Traceless Tandem Lesion Formation in DNA from a Nitrogen-Centered Purine Radical.Journal of the American Chemical Society · 2018Article
- Mechanism studies of addition reactions between the pyrimidine type radicals and their 3'/5' neighboring deoxyguanosines.RSC advances · 2018Article
- DNA Damage Emanating From a Neutral Purine Radical Reveals the Sequence Dependent Convergence of the Direct and Indirect Effects of γ-Radiolysis.Journal of the American Chemical Society · 2017Article
- Formation and processing of DNA damage substrates for the hNEIL enzymes.Free radical biology & medicine · 2017Review
- Pyrimidine Nucleobase Radical Reactivity in DNA and RNA.Radiation physics and chemistry (Oxford, England : 1993) · 2016Article
- Reactivity of Nucleic Acid Radicals.Advances in physical organic chemistry · 2016Article
- 5,6-Dihydropyrimidine peroxyl radical reactivity in DNA.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Reactive oxygen species (ROS) generate a type of DNA damage called tandem lesions, two adjacent nucleotides both modified. A subcategory of tandem lesions consists of adjacent nucleotides linked by a covalent bond. Covalently linked tandem lesions generate highly characteristic liquid chromotography-tandem mass spectrometry (LC-MS/MS) elution profiles. We have used this property to comprehensively survey X-irradiated DNA for covalently linked tandem lesions. A total of 15 tandem lesions were detected in DNA irradiated in deoxygenated aqueous solution, five tandem lesions were detected in DNA that was irradiated in oxygenated solution.
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Registered trials
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