ArticleJournal of experimental pathology (Oxford, England)1990
The microanatomy of the intrahepatic bile duct in polycystic disease: comparison of the cpk mouse and human.
Article in Journal of experimental pathology (Oxford, England), 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 27 citations in OpenAlex.
- Development of the bile ducts: essentials for the clinical hepatologist.Journal of hepatology · 2012Review
- Treatment of polycystic liver disease with resection-fenestration and a new classification.World journal of gastroenterology · 2008Article
- Surgical management of polycystic liver disease.World journal of gastroenterology · 2007Review
- Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease.The American journal of pathology · 2004Article
- Polycystic kidney rat is a novel animal model of Caroli's disease associated with congenital hepatic fibrosis.The American journal of pathology · 2001Article
- Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease.Pediatric nephrology (Berlin, Germany) · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cpk mutation in mice produces a lethal recessive form of polycystic kidney disease (PKD) that, like human forms of the condition, is associated with an age-related incidence of hepatic cysts. Injection of plastic into the biliary tree of affected animals revealed that these cysts arise from focal dilatations of the epithelial lining that may enlarge to the point that they obstruct the bile ducts. This concept was supported by histological and scanning and electron microscopic studies. No evidence could be found of primary obstruction of the biliary tree. The same techniques were then employed in specimens of human liver from patients with both recessive (ARPKD) and dominantly inherited PKD (ADPKD). Similar abnormalities of the biliary tree were identified. These abnormalities were not found in control liver samples from patients without PKD. The liver of the patient with ADPKD also demonstrated many von Meyenburg complexes. These were related to some cyst development, but these complexes freely communicated with bile ducts, contrary to currently held opinion. We conclude that hepatic abnormalities in the cpk mouse and human PKD arise from changes in bile ducts that are analogous to the renal lesions.
Indexed as
Identifiers
2310613PMC1998675W39663764What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.