ReviewComprehensive Physiology2012
Pulmonary circulation at exercise.
Review in Comprehensive Physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 170 citations in OpenAlex.
- Pulmonary haemodynamics and right heart function during exercise at high versus low altitude in patients with pulmonary vascular disease: a randomised crossover trial.Heart (British Cardiac Society) · 2025Trial
- Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure.Circulation. Heart failure · 2016Trial
- Swimming-Induced Pulmonary Edema: Pathophysiology and Risk Reduction With Sildenafil.Circulation · 2016Trial
- Right ventricular-pulmonary arterial coupling in transfusion-dependent thalassemia: a cross-sectional cardiac MRI study.European radiology · 2026Article
- The influence of metaboreflex activation on pulmonary pressure with combined chemoreflex activation in acute and chronic hypoxia.The Journal of physiology · 2026Article
- Knowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force.Pulmonary circulation · 2026Article
- Moderate Normobaric Hypoxia Does Not Exacerbate Left Ventricular Dysfunction After Exhaustive Exercise in Athletes and Untrained Individuals.Journal of clinical medicine · 2025Article
- Use of Echocardiography Under Hypoxic Stress Without Exercise to Assess Right to Left Shunting.Journal of cardiovascular development and disease · 2025Article
- Acute effects of 50 mg additive oral sildenafil on invasive exercise haemodynamics in pulmonary vascular disease.ERJ open research · 2025Article
- Cardiac output limits maximal oxygen consumption, but what limits maximal cardiac output?Experimental physiology · 2025Review
- Does stroke volume limit exercise capacity in TGA patients after the arterial switch operation?International journal of cardiology. Congenital heart disease · 2025Article
- Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling.American journal of physiology. Heart and circulatory physiology · 2025Article
- Relationship of Pulmonary Vascular Structure and Function With Exercise Capacity in Health and COPD.Chest · 2025Article
- Autonomic control of the pulmonary circulation: Implications for pulmonary hypertension.Experimental physiology · 2025Review
- Etorphine induces pathophysiology in immobilized white rhinoceros through sympathomimesis that is attenuated by butorphanol.Conservation physiology · 2025Article
- Submaximal, Low-Dose Eccentric vs Traditional Cycling Exercise: Reduced Oxygen Uptake and Pulmonary Artery Pressure Assessed by Echocardiography in Healthy Middle-aged Adults. A Randomized Controlled, Crossover Trial.Archives of rehabilitation research and clinical translation · 2024Article
- Lung fluid content during 6MWT in patients with COPD with and without comorbid heart failure.BMJ open respiratory research · 2024Article
- Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level.Physiological reports · 2024Article
- Impact of body position on hemodynamic measurements during exercise: A tale of two bikes.Pulmonary circulation · 2024Article
- Epicardial fat and Stage B heart failure among overweight/obese and normal weight individuals with diabetes mellitus.The international journal of cardiovascular imaging · 2023Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The pulmonary circulation is a high-flow and low-pressure circuit, with an average resistance of 1 mmHg/min/L in young adults, increasing to 2.5 mmHg/min/L over four to six decades of life. Pulmonary vascular mechanics at exercise are best described by distensible models. Exercise does not appear to affect the time constant of the pulmonary circulation or the longitudinal distribution of resistances. Very high flows are associated with high capillary pressures, up to a 20 to 25 mmHg threshold associated with interstitial lung edema and altered ventilation/perfusion relationships. Pulmonary artery pressures of 40 to 50 mmHg, which can be achieved at maximal exercise, may correspond to the extreme of tolerable right ventricular afterload. Distension of capillaries that decrease resistance may be of adaptative value during exercise, but this is limited by hypoxemia from altered diffusion/perfusion relationships. Exercise in hypoxia is associated with higher pulmonary vascular pressures and lower maximal cardiac output, with increased likelihood of right ventricular function limitation and altered gas exchange by interstitial lung edema. Pharmacological interventions aimed at the reduction of pulmonary vascular tone have little effect on pulmonary vascular pressure-flow relationships in normoxia, but may decrease resistance in hypoxia, unloading the right ventricle and thereby improving exercise capacity. Exercise in patients with pulmonary hypertension is associated with sharp increases in pulmonary artery pressure and a right ventricular limitation of aerobic capacity. Exercise stress testing to determine multipoint pulmonary vascular pressures-flow relationships may uncover early stage pulmonary vascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.