ArticleNeurodegenerative disease management2012
Essential tremor is not a neurodegenerative disease.
Article in Neurodegenerative disease management, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Neuroimaging essentials in essential tremor: a systematic review.NeuroImage. Clinical · 2014Pooled it
- Viral vector-mediated SLC9A6 gene replacement reduces cerebellar motor and molecular abnormalities in the shaker rat model of Christianson syndrome.Human molecular genetics · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Exploring the link between essential tremor and Parkinson's disease.NPJ Parkinson's disease · 2023Article
- GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats.Biomolecules · 2023Article
- Postmortem Cerebellar Volume Is Not Reduced in Essential Tremor: A Comparison with Multiple System Atrophy and Controls.Journal of Parkinson's disease · 2023Article
- Morphological and morphometric changes in the Purkinje cells of patients with essential tremor.Experimental and therapeutic medicine · 2022Article
- Encouraging a Generation of Tremor Researchers: Macdonald Critchley's Paper on Essential Tremor.Movement disorders clinical practice · 2022Article
- The Pathophysiology and Treatment of Essential Tremor: The Role of Adenosine and Dopamine Receptors in Animal Models.Biomolecules · 2021Review
- The Molecular Neuroimaging of Tremor.Current neurology and neuroscience reports · 2021Review
- Voxel-Based Morphometry of Cerebellar Lobules in Essential Tremor.Frontiers in aging neuroscience · 2021Article
- Cerebello-thalamo-cortical network is intrinsically altered in essential tremor: evidence from a resting state functional MRI study.Scientific reports · 2020Article
- Quantitative Separation of Tremor and Ataxia in Essential Tremor.Annals of neurology · 2020Article
- DNA methylome study of human cerebellar tissues identified genes and pathways possibly involved in essential tremor.Precision clinical medicine · 2019Article
- Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update. II. Hyperkinetic disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Emerging strategies in the management of essential tremor.Therapeutic advances in neurological disorders · 2017Review
- Knowledge gaps and research recommendations for essential tremor.Parkinsonism & related disorders · 2016Review
- Linking Essential Tremor to the Cerebellum: Neuropathological Evidence.Cerebellum (London, England) · 2016Review
- Essential Tremor: A Common Disorder of Purkinje Neurons?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2016Review
- Computational modeling to improve treatments for essential tremor.Drug discovery today. Disease models · 2016Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
The pathophysiology of essential tremor (ET) remains unknown. Standard neuropathological studies have reported no consistent changes but a detailed study found neurodegeneration in all ET cases - 24% demonstrated lower brainstem Lewy body (LB) inclusions and 76% experienced a loss of cerebellar Purkinje cells (PCs) and its sequelae. We review the evidence on neurodegeneration in ET. The prevalence of LB inclusions in ET brains is similar to that in the asymptomatic general population. These incidental LB disease cases have evidence for reduced striatal tyrosine hydroxylase levels, as found in Parkinson's disease, but there is no evidence for reduced tyrosine hydroxylase levels in ET patients. Reduced mean PC counts in ET cases compared with the controls reported by some studies could not be replicated by others. Most ET cases have the same number of PCs as controls of a comparable age. Neither the lower brainstem LB inclusions nor the cerebellar PC loss represent the neurodegenerative basis of ET. Further studies are needed to determine the pathophysiology of ET.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.