ArticleIndian journal of clinical biochemistry : IJCB2009
Escherichia coli lipopolysaccharide administration alters antioxidant profile during hypercholesterolemia.
Article in Indian journal of clinical biochemistry : IJCB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Comparative immunomodulatory efficacy of rosemary and fenugreek against Escherichia coli infection via suppression of inflammation and oxidative stress in broilers.Environmental science and pollution research international · 2022Article
- Selected spices and their combination modulate hypercholesterolemia-induced oxidative stress in experimental rats.Biological research · 2014Article
- Protective effect of T. violacea rhizome extract against hypercholesterolemia-induced oxidative stress in Wistar rats.Molecules (Basel, Switzerland) · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Pathogens, especially Gram-negative bacteria or bacterial endotoxin, along with other classical factors, may be involved in inflammatory response within the aortic endothelium during the progression of cardiovascular disease. Studies have shown that bacterial endotoxin activates various inflammatory processes in the body. Our study aims to establish a correlation between endotoxemia and vascular expression of antioxidant enzymes. Swiss albino mice (4 weeks old) were fed a high fat diet for 24 weeks and then were administered Escherichia coli endotoxin intraperitonealy, for 4 weeks. Tissue antioxidant enzymes, serum levels of IL-6 and TNF alpha were measured from the mice. We report that i.p. administration of endotoxin to hyperlipidemic mice resulted in elevation of superoxide dismutase and catalase enzymes, which was paralleled by a systemic reduction of serum cholesterol and LDL expression. Myeloperoxidase levels were also found to be elevated in aortic tissue, while an increase was also observed in the serum cytokine levels.
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