ArticleIndian journal of clinical biochemistry : IJCB2008
Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications.
Article in Indian journal of clinical biochemistry : IJCB, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 49 citations in OpenAlex.
- Hemoglobin A1C: Intracellular Heterogeneity and Functional Implications in Prediabetic and T2 Diabetic Erythrocytes.International journal of molecular sciences · 2025Article
- Article
- Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress - a brief review.Frontiers in chemistry · 2025Review
- Serum ferritin level and associated factors among uncontrolled adult type II diabetic follow-up patients: comparative based cross-sectional study.BMC endocrine disorders · 2024Article
- Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study.Reports of biochemistry & molecular biology · 2020Article
- Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus.Medical sciences (Basel, Switzerland) · 2016Article
- Altered Concentrations of Copper, Zinc, and Iron are Associated With Increased Levels of Glycated Hemoglobin in Patients With Type 2 Diabetes Mellitus and Their First-Degree Relatives.International journal of endocrinology and metabolism · 2016Article
- Glycated hemoglobin and its spinoffs: Cardiovascular disease markers or risk factors?World journal of cardiology · 2015Article
- Glucose-6-Phosphate Dehydrogenase Activity and Protein Oxidative Modification in Patients with Type 2 Diabetes Mellitus.Journal of biomarkers · 2013Article
- Copper and ceruloplasmin levels in relation to total thiols and GST in type 2 diabetes mellitus patients.Indian journal of clinical biochemistry : IJCB · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Free iron in serum has been found in several disease conditions including diabetes. In the present work, we studied the relationship between free iron, fasting blood glucose (FBG) and glycated haemoglobin (HbA(1c)). Study was carried out on 50 type 2 diabetes cases under poor glycemic control associated with complications, 53 type 2 diabetes cases under good glycemic control and 40 healthy controls. We estimated free iron, both ferrous (Fe(+2)) and ferric (Fe(+3)) form, protein thiols, lipid hydroperoxides, FBG, HbA1c and serum ferritin levels in serum. There was a significant increase in free iron in Fe(+3) state (p <0.01), HbA(1c) (p<0.01), serum ferritin (p<0.01), lipid hydroperoxides (p<0.01) and significant decrease in protein thiols (<0.01) in diabetes cases under poor glycemic control compared to diabetes cases under good glycemic control and healthy controls. Free iron correlated positively with HbA(1c) (p<0.01). Poor glycemic control and increase in glycation of haemoglobin is contributing to the increase in free iron pool which is known to increase oxidant generation.
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