ArticleIndian journal of clinical biochemistry : IJCB2006
Estradiol regulates insulin dependent stimulation of LDL-receptor expression in HepG(2) cells.
Article in Indian journal of clinical biochemistry : IJCB, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 11 citations in OpenAlex.
- Differential Response of B Cells to an Immunogen, a Mitogen and a Chemical Carcinogen in a Mouse Model SystemAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Role of leptin on the expression of low density lipoprotein receptor.The Indian journal of medical research · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
The low density lipoprotein, one of the major vehicle for extraneous cholesterol, internalizes into the cells through the process of LDL-receptor mediated endocytosis. The expression of LDL-receptor on the cell surface is a function of various hormone regulated transcription of the receptor gene. The present study elucidates the differential expression pattern of LDL-receptor protein in human hepatoma HepG(2) cells by the influence of two hormones, insulin and estrogen (β-estradiol), as compared to the basal level expression of the receptor protein. The combined effect of insulin and β-estradiol reveals that β-estradiol is the ultimate regulator between these two hormones and supershades the message of insulin on LDL-receptor expression. The receptor protein level immunobloted by anti LDL-receptor antibody after treating cells with insulin, β-estradiol and mixture of both also reflects the same phenomena. This comparative study makes it consistent that cell saturation with sterol (β-estradiol) is the prime regulator of LDL-receptor expression between the two hormones, insulin and estrogen.
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Registered trials
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