ArticleIndian journal of clinical biochemistry : IJCB2005
Autoimmune thyroid disorders-An update.
Article in Indian journal of clinical biochemistry : IJCB, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 92 citations in OpenAlex.
- The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto's Disease.Nutrients · 2021Trial
- MRI quantitative assessment of the effects of low-carbohydrate therapy on Hashimoto's thyroiditis.Endocrine connections · 2024Article
- Mechanisms and Treatment Options for Hyperthyroid-Induced Osteoporosis: A Narrative Review.Cureus · 2023Review
- The Role of Toll-like Receptor 2 (TLR2) in the Development and Progression of Hashimoto's Disease (HD): A Case Study on Female Patients in Poland.International journal of molecular sciences · 2023Article
- Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry.Pediatric rheumatology online journal · 2023Article
- Association between dental caries experience and salivary profile among autoimmune thyroid disease subjects - a cross-sectional comparative study.F1000Research · 2023Article
- Autoimmune Thyroid Disease in Patients with Hypovitaminosis D in Department of Biochemistry of a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2022Article
- A U-shaped association between serum albumin with total triiodothyronine in adults.Journal of clinical laboratory analysis · 2022Article
- Review
- Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Human gene and disease associations for clinical-genomics and precision medicine research.Clinical and translational medicine · 2020Article
- The Role ofFrontiers in endocrinology · 2019Article
- Assessment of Iodine Status among Pregnant Women and Neonates Using Neonatal Thyrotropin (TSH) in Mainland China after the Introduction of New Revised Universal Salt Iodisation (USI) in 2012: A Re-Emergence of Iodine Deficiency?International journal of endocrinology · 2019Article
- Autoantibody against aldehyde dehydrogenase 2 could be a biomarker to monitor progression of Graves' orbitopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- Association between thyroid hormones and the components of metabolic syndrome.BMC endocrine disorders · 2018Article
- The Relationship of TPOAb and TGAb with Risk of Thyroid Nodules: A Large Epidemiological Study.International journal of environmental research and public health · 2017Article
- Estimation of Salivary Parameters among Autoimmune Thyroiditis Patients.Journal of clinical and diagnostic research : JCDR · 2017Article
- Article
- Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases.Frontiers in immunology · 2017Review
- Is papillary thyroid microcarcinoma an indolent tumor?: A retrospective study on 280 cases treated with radioiodine.Medicine · 2016Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutoimmune thyroid disease (AITD), a common organ specific autoimmune disorder is seen mostly in women between 30-50 yrs of age. Thyroid autoimmunity can cause several forms of thyroiditis ranging from hypothyroidism (Hashimoto's thyroiditis) to hyperthyroidism (Graves'Disease). Prevalence rate of autoimmune mediated hypothyroidism is about 0.8 per 100 and 95% among them are women. Graves' disease is about one tenth as common as hypothyroidism and tends to occur more in younger individuals. Both these disorders share many immunologic features and the disease may progress from one state to other as the autoimmune process changes. Genetic, environmental and endogenous factors are responsible for initiation of thyroid autoimmunity. At present the only confirmed genetic factor lies in HLA complex (HLA DR-3) and the T cell regulatory gene (CTLA 4). A number of environmental factors like viral infection, smoking, stress & iodine intake are associated with the disease progression. The development of antibodies to thyroid peroxidase (TPO) thyroglobulin (TG) and Thyroid stimulating hormone receptor (TSH R) is the main hallmark of AITD. Circulating T Lymphocytes are increased in AITD and thyroid gland is infiltrated with CD4+ and CD8+ T Cells. Wide varieties of cytokines are produced by infiltrated immune cells, which mediate cytotoxicity leading to thyroid cell destruction. Circulating antibodies to TPO and TG are measured by immunofluorescense, hemagglutination, ELISA & RIA. TSHR antibodies of Graves' disease can be measured in bioassays or indirectly in assays that detect antibody binding to the receptor.
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