Evidence map›Paper›PMID 23105177›Full record

ArticleIndian journal of clinical biochemistry : IJCB1998

LP(a) phenotypes and levels in angiographically proven coronary heart disease patients and controls.

K Luthra, S Vasisht, S Chhabra, K R Raju, D P Agarwal, S C Manchanda, L M Srivastava

Abstract read
In one paragraph

Article in Indian journal of clinical biochemistry : IJCB, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Lipoprotein (a): a Unique Independent Risk Factor for Coronary Artery Disease.Indian journal of clinical biochemistry : IJCB · 2016
    Review
  2. Lipid profile in middle class Bengali population of Kolkata.Indian journal of clinical biochemistry : IJCB · 2003
    Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

K LuthraDepartment of Biochemistry, CN Centre, All India Institute of Medical Sciences, 110029 New Delhi.
S Vasisht
S Chhabra
K R Raju
D P Agarwal
S C Manchanda
L M Srivastava

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein Lp(a) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. To evaluate this in a North-Indian population, 130 CAD patients and 130 controls were analyzed. The size of the apo(a) phenotypic isoforms was inversely proportional to Lp(a) concentrations. The mean concentration of Lp(a) in the CAD patients was 42±34 mg/dl whereas in the normal subjects it was much lower, 27±27 mg/dl. 157 subjects out of the total 260 subjects showed plasma levels of >20mg/dl. The frequency of high Lp(a) levels was much higher in patients(73%) than controls (43%). These data suggest (1) that there is heterogeneity of the Lp(a) polymorphism, (2) Higher Lp(a) levels were found in patients than in the controls, (3) Patients showed 1.5 fold increase in Lp(a) levels as compared to the controls. We conclude that low molecular weight apo(a) isoforms are significantly associated with increased risk of CAD in the North-Indian population.

Indexed as

Apolipoprotein(a)CholesterolCoronary artery diseaseLipoprotein(a)

Identifiers

PMID23105177
PMCPMC3453536

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